健脾消萎汤联合胶体果胶铋胶囊治疗对慢性萎缩性胃炎患者胃泌素17、胃蛋白酶原、炎性因子水平的影响  

Therapeutic Effect of Jianpi Xiaowei Decoction Combined with Colloidal Pectin Bismuth Capsules on Chronic Atrophic Gastritis and Its Effects on Levels of Gastrin 17,Pepsinogen,and Inflammatory Factors

作　　者：陈兴慧 谢睿 刘瑶 张靖琨 李璞 冀花 CHEN Xinghui;XIE Rui;LIU Yao;ZHANG Jingkun;LI Pu;JI Hua(Spleen and Stomach Disease Department of Hanzhong Traditional Chinese Medicine Hospital,Shaanxi Hanzhong 723100,China;Integrated Traditional Chinese and Western Medicine Department of Shangluo Central Hospital,Shaanxi Shangluo 726000,China)

机构地区：[1]汉中市中医医院脾胃病科,陕西汉中723100 [2]商洛市中心医院中西医结合科,陕西商洛726000

出　　处：《现代中医药》2024年第1期74-78,共5页Modern Chinese Medicine

基　　金：陕西省中医药管理局基金项目(SZY-NLTL-2022-029)。

摘　　要：目的观察健脾消萎汤联合胶体果胶铋胶囊治疗慢性萎缩性胃炎对患者胃泌素-17(gastrin 17,G-17)、胃蛋白酶原(pepsinogen,PG)、炎性因子水平的影响。方法选取2019年6月—2022年6月前来我院治疗的慢性萎缩性胃炎患者80例,随机分为对照组(40例,胶体果胶铋胶囊)、治疗组(40例,胶体果胶铋胶囊+健脾消萎汤),均给予基础治疗,评估疗效,测量血清炎性因子及PG、GAS-17水平。结果治疗组总有效率显著高于对照组(P<0.05);治疗后治疗组血清白介素(interleukin,IL)-2、IL-6水平显著低于对照组(P<0.05);治疗后治疗组血清PGⅠ、G-17水平显著高于对照组,PGⅡ水平显著低于对照组(P<0.05)。结论健脾消萎汤联合胶体果胶秘胶囊治疗慢性萎缩性胃炎可减轻患者炎症反应,改善PG及G-17水平,缓解患者临床症状,整体疗效确切。Objective To study the effects of Jianpi Xiaowei decoction combined with colloidal pectin bismuth capsules on the levels of gastrin-17(G-17),pepsinogen(PG),and inflammatory factors in patients with chronic atrophic gastritis.Methods Eighty patients with chronic atrophic gastritis who came to our hospital for treatment from June 2019 to June 2022 were selected and randomly divided into a control group(40 cases,colloidal pectin bismuth capsules)and a treatment group(40 cases,colloidal pectin bismuth capsules+Jianpi Xiaowei decoction).Both groups were given basic treatment,and the therapeutic effect was evaluated.Serum inflammatory factors,PG,and GAS-17 levels were measured.Results The total effective rate of the treatment group was significantly higher than that of the control group(P<0.05);After treatment,the serum levels of interleukin-2(IL-2)and IL-6 in the treatment group were significantly lower than those in the control group(P<0.05);After treatment,the serum levels of PGI and G-17 in the treatment group were significantly higher than those in the control group,while the levels of PGII were significantly lower than those in the control group(P<0.05).Conclusion The combination of Jianpi Xiaowei decoction and colloidal pectin secret capsules can alleviate inflammation,improve PG and G-17 levels,alleviate clinical symptoms in patients with chronic atrophic gastritis,and have a definite overall therapeutic effect.

关 键 词：慢性萎缩性胃炎 健脾消萎汤 胶体果胶秘胶囊 胃泌素-17 胃蛋白酶原 

分 类 号：R256.3[医药卫生—中医内科学]