新型妥曲珠利均质混悬液在鸡体内药代动力学研究  

Pharmacokinetics of a New Toltrazuril Homogeneous Suspension in Chicken

作　　者：华添 贺文庆 毕瑜林[1] 白皓 王志秀 江勇 常国斌[1,3] HUA Tian;HE Wenqing;BI Yulin;BAI Hao;WANG Zhixiu;JIANG Yong;CHANG Guobin(College of Animal Science and Technology,Yangzhou University,Yangzhou,Jiangsu 225009;Agricultural Technology Comprehensive Service Center of Yizheng,Yangzhou,Jiangsu 211400;Joint Laboratory of International Cooperation on Agriculture and Agricultural Product Safety,Ministry of Education,Institute of Agricultural Science and Technology Development,Yangzhou University,Yangzhou,Jiangsu 225009)

机构地区：[1]扬州大学动物科学与技术学院,江苏扬州225009 [2]仪征市农业技术综合服务中心,江苏扬州211400 [3]扬州大学农业科技发展研究院,教育部农业与农产品安全国际合作联合实验室,江苏扬州225009

出　　处：《中国家禽》2024年第1期114-118,共5页China Poultry

基　　金：现代农业产业技术体系建设专项资金(CARS-41);江苏省333人才工程项目(BRA2020077)。

摘　　要：为评价新型妥曲珠利均质混悬液在鸡体内的吸收和代谢情况,试验将16只35日龄健康青脚麻鸡随机分成2组(公母各半),其中对照组经口灌服常规妥曲珠利混悬液,受试药物组经口灌服新型妥曲珠利均质混悬液,剂量均为20 mg/kg(以妥曲珠利计)。给药后在设定时间段经翅静脉采血,分析血浆中妥曲珠利血药浓度。结果显示:新型妥曲珠利均质混悬液平均消除半衰期(T_(1/2β))约为11.13 h,达峰时间(T_(max))为2.0 h,达峰值浓度(C_(max))为26.26μg/mL,均与妥曲珠利混悬液差异不显著(P>0.05),新型妥曲珠利均质混悬液平均药时曲线下面积(AUC)和平均滞留时间(MRT)分别为325.70μg/mL·h和13.04 h,与妥曲珠利混悬液差异显著(0.01<P<0.05),新型妥曲珠利均质混悬液相对生物利用度(F)为105.54%。研究表明,新型妥曲珠利均质混悬液具备与妥曲珠利混悬液相同的药动学特征,并且使用更方便。To evaluate the absorption and metabolism of a new toltrazuril homogeneous suspension in chicken,sixteen healthy 35-day-age Blueshank Partridge hens were randomly divided into two groups(half male and half female),birds in the control group were received the conventional toltrazuril suspension orally and birds in the test drug group were received a new tol⁃trazuril homogeneous suspension orally,and the dose of 20 mg/kg(in toltrazuril)was for both groups.After administration,blood was collected from a wing vein at a set time and plasma concentrations of toltrazuril were analysed.The results showed that the mean elimination half-life(T_(1/2β))of the new toltrazuril homogeneous suspension was about 11.13 h,a peak time(T_(max))of which was 2.0 h,the peak concentration(C_(max))of which was 26.26μg/mL,which were not significantly different with toltrazuril suspension(P>0.05).The mean area under the curve(AUC)and mean retention time(MRT)of the new toltrazuril homogeneous suspension were 325.70μg/mL·h and 13.04 h,respectively,which were significantly different with toltrazuril suspension(0.01<P<0.05),and the relative bioavailability(F)of the new toltrazuril homogeneous suspension was 105.54%compared to toltrazuril suspension.It's indicated that the new toltrazuril homogeneous suspension had the same pharmacokinetic characteristics as the toltrazuril suspen⁃sion,and was more convenient and easier to handle.

关 键 词：妥曲珠利 混悬液 鸡 药代动力学 

分 类 号：S859.7[农业科学—临床兽医学]