关苍术亲脂性化学成分研究  

Study on Lipophilic Chemical Constituents of Atractylodes japonica

作　　者：周媛媛[1] 孙杰 江冰悦 杨咏琪 董柯杉 王萍 方振兴[3] 张晓娟[1] ZHOU Yuanyuan;SUN Jie;JIANG Bingyue;YANG Yongqi;DONG Keshan;WANG Ping;FANG Zhenxing;ZHANG Xiaojuan(Key Laboratory of Basic and Application Research of Beiyao of Ministry of Education,and Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang Academy of Chinese Medical Sciences,Harbin 150036,China;Institute of Natural Resources and Ecology,Heilongjiang Academy of Sciences,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,教育部北药基础与应用研究重点实验室,黑龙江哈尔滨150040 [2]黑龙江省中医药科学院,黑龙江哈尔滨150036 [3]黑龙江省科学院自然与生态研究所,黑龙江哈尔滨150040

出　　处：《中医药信息》2024年第1期32-35,43,共5页Information on Traditional Chinese Medicine

基　　金：黑龙江省自然科学基金项目(LH2019H048);黑龙江省“头雁”团队支持项目(黑龙江省头雁行动领导小组文件[2019]5号);黑龙江省博士后科研启动金资助项目(LBH-Q16207);黑龙江省大学生创新创业训练计划项目(S202310228067);黑龙江中医药大学新药研究基金(2018xy02)。

摘　　要：目的:研究关苍术亲脂性成分的化学成分。方法:使用硅胶柱色谱、Sephadex LH-20柱色谱、中压液相色谱和半制备HPLC等方法对关苍术中的化学成分进行分离纯化,并通过理化性质和MS与NMR等波谱技术对其化学成分进行结构鉴定。结果:从关苍术药材中分离并鉴定了12种化合物,分别鉴定为osthol(1)、Atractylochromene(2)、6,7-二羟基-8-甲氧基香豆素(3)、8-羟基-6,7-二甲氧基香豆素(4)、7-甲氧基香豆素(5)、豆甾-4-烯-3-酮(6)、蒲公英萜醇乙酸酯(7)、白术内酯Ⅱ(8)、白术内酯Ⅰ(9)、桉叶-4(15)-烯-7β,11-二醇(10)、反式对羟基桂皮酸甲酯(11)、丁香醛(12)。结论:化合物1,3~6,10~12为首次从关苍术中分离的化合物。Objective:To study the lipophilic chemical constituents of Atractylodes japonica.Methods:The chemical constituents of Atractylodes japonica were isolated and purified through the methods such as silica gel column chromatography,Sephadex LH-20 column chromatography,medium pressure liquid chromatography,and semi-preparative HPLC;and the structural identification of the components was conducted through physicochemical properties and MS and NMR spectroscopy techniques.Results:Twelve compounds were isolated and identified from Atractylodes japonica,which are osthol(1),atractylochromene(2),6,7-dihydroxy-8-methoxycoumarin(3),8-hydroxy-6,7-dimethoxycoumarin(4),7-methoxycoumarin(5),stigmast-4-en-3-one(6),taraxeryl acetate(7),atractylenolideⅡ(8),atractylenolideⅠ(9),eucalyptus-4(15)-ene-7β,11-diol(10),methyl 4-hydroxycinnamate(11),syringaldehyde(12).Conclusion:Compounds 1,3-6,10-12 are the first isolated compounds from Atractylodes japonica.

关 键 词：关苍术 化学成分 理化性质 分离鉴定 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]