苄星青霉素与普鲁卡因青霉素治疗妊娠期梅毒的效果比较  

Comparison of the Effect of Benzathine Penicillin and Procaine Penicillin in the Treatment of Syphilis During Pregnancy

作　　者：黄晓霞 黄桂英 郑振芳 李京 HUANG Xiaoxia;HUANG Guiying;ZHENG Zhenfang;LI Jing(Obstetrics and Gynecology Department of Fujian Fu’an Maternal and Child Health Care Hospital,Fu’an 355000,Fujian,China)

机构地区：[1]福安市妇幼保健院妇产科,福建福安355000

出　　处：《中国药物滥用防治杂志》2023年第12期2173-2176,2180,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:比较苄星青霉素与普鲁卡因青霉素治疗妊娠期梅毒的疗效,并探讨其对母婴不良结局的影响因素。方法:选取本院产科门诊2017年11月—2021年11月收治的妊娠期梅毒患者169例,基于治疗方式差异分成B组(苄星青霉素治疗,n=84)和P组(普鲁卡因青霉素治疗,n=85),比较两组疗效指数、梅毒阻断情况及不良结局发生情况;根据患者的妊娠结局将其分成正常妊娠组(n=135)和不良妊娠组(n=34),比较两组临床资料,并应用Logistic回归分析不良结局影响因素。结果:B组疗效指数、梅毒阻断率、不良结局发生率分别为84.52%、82.14%、17.86%,与P组的78.82%、78.82%、22.35%比较,差异均无统计学意义(P>0.05)。单因素分析显示:不良妊娠组婚姻状况为未婚或离异比例、梅毒分期为早期比例、就诊时TRUST滴度大于1∶8比例均大于正常妊娠组(P<0.05)。Logistic回归分析显示:婚姻状况、梅毒分期、就诊时TRUST滴度是母婴不良结局的独立危险因素(P<0.05)。结论:苄星青霉素与普鲁卡因青霉素治疗妊娠期梅毒疗效相当,婚姻状况、梅毒分期、就诊时TRUST滴度与患者不良妊娠结局相关密切,临床应予以重视。Objective:To compare the efficacy of benzathine penicillin and procaine penicillin in the treatment of syphilis during pregnancy,and to explore the influencing factors of maternal and infant adverse outcomes.Methods:A total of 169 patients with syphilis during pregnancy admitted to the obstetrics clinic of our hospital from November 2017 to November 2021 were selected and divided into group B(benzathine penicillin treatment,n=84)and group P(procaine penicillin treatment,n=85)based on different treatment methods.The efficacy index,syphilis blocking and adverse outcomes were compared between the two groups.According to the pregnancy outcome of the patients,they were divided into normal pregnancy group(n=135)and adverse pregnancy group(n=34).The clinical data of the two groups were compared,and the influencing factors of adverse outcomes were analyzed by Logistic regression.Results:The efficacy index,syphilis blocking rate and incidence of adverse outcomes in group B were 84.52%,82.14%and 17.86%,respectively,which were not significantly different from 78.82%,78.82%and 22.35%in group P(P>0.05).Univariate analysis showed that the proportion of unmarried or divorced marital status,the proportion of early syphilis stage,and the proportion of TRUST titer greater than 1:8 in the adverse pregnancy group were higher than those in the normal pregnancy group(P<0.05).Logistic regression analysis showed that marital status,syphilis stage and TRUST titer were independent risk factors for maternal and infant adverse outcomes(P<0.05).Conclusion:The efficacy of benzylpenicillin and procaine penicillin in the treatment of syphilis during pregnancy is comparable.Marital status,syphilis staging,and TRUST titer at the time of treatment are closely related to adverse pregnancy outcomes in patients,and clinical attention should be paid to them.

关 键 词：妊娠期梅毒 苄星青霉素 普鲁卡因青霉素 临床疗效 妊娠结局 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R714.25[医药卫生—临床医学]