多索茶碱联合BiPAP治疗慢阻肺急性加重期老年患者的效果观察  

Observation on the Effect of Doxofylline Combined with BiPAP in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease in the Elderly

作　　者：朱婕琳[1] 吕智[1] ZHU Jielin;LV Zhi(Zhongshan Hospital of Xiamen University,Xiamen 361000,Fujian,China)

机构地区：[1]厦门大学附属中山医院,福建厦门361000

出　　处：《中国药物滥用防治杂志》2023年第12期2196-2198,共3页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：厦门市科学技术基金项目(编号:2060203)。

摘　　要：目的:探讨多索茶碱联合BiPAP治疗慢阻肺(COPD)急性加重期老年患者的治疗效果。方法:选取2020年1月—2023年1月厦门大学附属中山医院收治的COPD急性加重期老年患者80例,随机分为对照组、观察组,各40例。对照组采取双水平气道正压通气(BiPAP)治疗,观察组则采取BiPAP+多索茶碱联合治疗。比较两组治疗效果、肺功能指标变化情况及不良反应发生率。结果:观察组总有效率为97.50%,高于对照组的85.00%(P<0.05);观察组治疗后FVC、FEV_(1)、FEV_(1)/FVC水平均高于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。结论:针对COPD急性加重期老年患者,多索茶碱联合BiPAP治疗较单一治疗效果较好,通过联合用药可产生协同性,能够有效缓解患者临床症状,改善其肺功能,减少不良反应发生情况。Objective:To investigate the therapeutic effect of doxofylline combined with BiPAP in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods:A total of 80 elderly patients with acute exacerbation of COPD admitted to our hospital from January 2020 to January 2023 were randomly divided into control group and observation group,with 40 patients in each group.The control group was treated with bi-level positive airway pressure(BiPAP),while the observation group was treated with BiPAP+doxofylline.The therapeutic effect,changes of pulmonary function indexes and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.50%,which was higher than 85.00%of the control group(P<0.05).After treatment,the levels of FVC,FEV_(1) and FEV_(1)/FVC in the observation group were higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:For elderly patients with acute exacerbation of COPD,doxofylline combined with BiPAP is more effective than single treatment.Synergism can be produced by combined medication,which can effectively alleviate the clinical symptoms of patients,improve their lung function and reduce the occurrence of adverse reactions.

关 键 词：多索茶碱 BIPAP 慢阻肺 急性加重期 疗效 

分 类 号：R563.9[医药卫生—呼吸系统]