系统性红斑狼疮病人衰弱现状及其影响因素分析  

Status and influencing factors of frailty in patients with systemic lupus erythematosus

作　　者：张雨歌 洪静芳[1] 张海玲 张敏[2] ZHANG Yu-ge;HONG Jing-fang;ZHANG Hai-ling;ZHANG Min(School of Nursing,Anhui Medical University,Hefei Anhui 230032;Department of Rheumatology and Immunology,The First Affiliated Hospital of University of Science and Technology of China,Anhui Provincial Hospital,Hefei Anhui 230002,China)

机构地区：[1]安徽医科大学护理学院,安徽合肥230032 [2]中国科学技术大学附属第一医院,安徽省立医院风湿免疫科,安徽合肥230002

出　　处：《蚌埠医学院学报》2023年第12期1739-1743,共5页Journal of Bengbu Medical College

基　　金：安徽省自然科学基金项目(1808085MH298)。

摘　　要：目的:探究系统性红斑狼疮(SLE)病人衰弱现状并分析其影响因素。方法:运用便利抽样法选取203例SLE病人作为研究对象。应用一般资料调查表、中文版Tilburg衰弱量表、Charlson合并症指数(Charlson comorbidity index, CCI)及Barthel评定量表对研究对象进行调查。结果:SLE病人衰弱得分7(7,10)分,衰弱的发生率为73.9%。合并症指数评分在2分以上的占56.2%。Barthel评定量表得分(90.05±15.64)分。Spearman相关分析结果表明,衰弱和多重用药(rs=0.215)、CCI(rs=0.485)呈正相关关系(P<0.05),与自理能力呈负相关关系(rs=-0.538,P<0.01)。多元线性回归分析结果显示,年龄增大、CCI得分高、BI得分低、多重用药等可能是系统性红斑狼疮病人衰弱得分高的独立危险因素(P<0.05~P<0.01)。结论:SLE病人的衰弱发生率较高,医务人员应早期识别病人衰弱并制定和实施个性化的干预措施,降低衰弱的发生率。Objective To explore the frailty status of patients with systemic lupus erythematosus(SLE)and analyze its influencing factors.Methods A convenience sampling method was performed to select 203 patients with SLE as the research subjects.The general data questionnaire,Chinese version of Tilburg frailty scale,Charlson comorbidity index(CCI)and Barthel index were used to investigate the research subjects.Results The frailty score of patients with SLE was 7(7,10)points,the morbidity of frailty was 73.9%.The Charlson comorbidity index score was above 2 points in 56.2%.The Barthel index score was(90.05±15.64)points.Spearman correlation analysis showed that the frailty was positively correlated with polypharmacy(rs=0.215),CCI(rs=0.485)(P<0.05),and negatively correlated with self-care ability(rs=-0.538,P<0.01).The results of the multiple linear regression analysis showed that increased age,high CCI scores,low BI scores and polypharmacy might be independent risk factors for high frailty scores in patients with SLE(P<0.05 to P<0.01).Conclusions The incidence of frailty in SLE patients is high.Medical staff should identify frailty early,formulate and implement individualized intervention measures to reduce its incidence.

关 键 词：系统性红斑狼疮 衰弱 影响因素 

分 类 号：R593.241[医药卫生—内科学]