老年2型糖尿病并发骨质疏松症患者血清网膜素-1及氧化应激参数的表达  

Expression of Serum Omentin-1 and Oxidative Stress Parameters in Elderly Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis

作　　者：李宗虎 朱明明[2] 郑宪玲[2] 王颖霞[2] 张树杰[2] Li Zonghu;Zhu Mingming;Zheng Xianling;Wang Yingxia;Zhang Shujie(Department of Physical Examination,Handan Central Hospital,Handan 056001;Department of Endocrinology,Handan Central Hospital,Handan 056001)

机构地区：[1]邯郸市中心医院健康体检科,邯郸056001 [2]邯郸市中心医院内分泌科,邯郸056001

出　　处：《国际老年医学杂志》2024年第1期82-86,共5页International Journal of Geriatrics

基　　金：河北省医学科学研究课题(20210509)。

摘　　要：目的探讨老年2型糖尿病(T2DM)并发骨质疏松症患者血清网膜素-1(Omentin-1)及氧化应激参数的表达情况。方法选取邯郸市中心医院2020年1月—2023年1月收治的148例老年T2DM患者进行前瞻性研究,按骨密度T值大小将其分成骨量正常组(51例)、骨量减少组(45例)和骨质疏松症组(52例),检测各组血清Omentin-1、总超氧化物歧化酶(T-SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、核因子-E2相关因子2(Nrf2)、血红素氧合酶-1(HO-1)等氧化应激参数的表达情况。结果骨质疏松症组、骨量减少组血清Omentin-1、T-SOD、GSH-Px、Nrf2水平低于骨量正常组(P<0.05),且骨质疏松症组血清Omentin-1、T-SOD、GSH-Px、Nrf2水平低于骨量减少组(P<0.05)。骨质疏松症组、骨量减少组血清MDA、HO-1水平高于骨量正常组(P<0.05),且骨质疏松症组血清MDA、HO-1水平高于骨量减少组(P<0.05)。结论血清Omentin-1、T-SOD、GSH-Px、MDA、Nrf2和HO-1在老年T2DM并发骨质疏松症患者中均呈异常表达,这些指标可作为老年T2DM并发骨质疏松症患者氧化应激反应评估与治疗的参考依据。Objective To investigate the expression of serum omentin - 1 and oxidative stress parameters in elderly patientswith type 2 diabetes mellitus ( T2DM) complicated with osteoporosis. Methods A prospective study was conducted in 148 elderlypatients with T2DM admitted to Handan Central Hospital from January 2020 to January 2023. According to the T value of bone mineraldensity,the patients were divided into a normal bone mass group ( 51 cases) ,a osteopenia group ( 45 cases) and an osteoporosisgroup ( 52 cases) . The expression of oxidative stress parameters such as serum Omentin - 1,total superoxide dismutase ( T - SOD) ,malondialdehyde ( MDA) ,glutathione peroxidase ( GSH - Px) ,nuclear factor - E2 related factor 2 ( Nrf2) and heme oxygenase - 1( HO - 1) was detected. Results The serum levels of Omentin - 1,T - SOD,GSH - Px and Nrf2 in the osteoporosis group and theosteopenia group were lower than those in the normal bone mass group ( P < 0. 05) ,and the serum levels of Omentin - 1,T - SOD,GSH - Px and Nrf2 in the osteoporosis group were lower than those in the osteopenia group ( P < 0. 05) . The levels of MDA and HO -1 in the osteoporosis group and osteopenia group were higher than those in the normal bone mass group ( P < 0. 05) ,and the levels ofMDA and HO - 1 in osteoporosis group were higher than those in the osteopenia group ( P < 0. 05) . Conclusion Serum Omentin -1,T - SOD,GSH - Px,MDA,Nrf2 and HO - 1 were abnormally expressed in elderly patients with T2DM complicated with osteoporosis,and these indicators can be used as a reference for oxidative stress response assessment and treatment in elderly patients withT2DM complicated with osteoporosis.

关 键 词：2型糖尿病 骨质疏松症 网膜素-1 氧化应激参数 

分 类 号：R580[医药卫生—内分泌] R587.2[医药卫生—内科学]