强直性脊柱炎患者血清HLA-B27、BALP、CD14水平与病程及骨代谢指标的相关性  

Relationship between serum levels of HLA-B27, BALP, CD14 and disease course and bone metabolism indexes in patients with ankylosing spondylitis

作　　者：张毓静 孙亚洲 宋琛 Zhang Yujing;Sun Yazhou;Song Chen(Department of Genetics,the First Afiliated Hospital of Xinxiang Medical College,Weihui 453100,China;Department of Pediatrics,the First Afiliated Hospital of Xinxiang Medical College,Weihui 453100,China;Department of Hematology Laboratory,the First Afiliated Hospital of Xinxiang Medical College,Weihui 453100,China)

机构地区：[1]新乡医学院第一附属医院遗传科,河南卫辉453100 [2]新乡医学院第一附属医院儿科,河南卫辉453100 [3]新乡医学院第一附属医院血液学实验室,河南卫辉453100

出　　处：《临床医学》2023年第12期5-8,共4页Clinical Medicine

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190444,LHGJ20210518);新乡医学院第一附属医院青年培育基金(QN-2019-A08)。

摘　　要：目的研究强直性脊柱炎患者血清人类白细胞抗原B27(HLA-B27)、骨碱性磷酸酶(BALP)、人可溶性CD14(CD14)水平与预后及骨代谢指标的关系。方法选取2020年4月至2022年12月在新乡医学院第一附属医院治疗的强直性脊柱炎患者60例为观察组,另选取同期本院健康体检者60例为对照组。观察组患者根据病情进展分为早期28例,中期21例,晚期11例。比较两组血清HLA-B27、BALP、CD14水平,研究强直性脊柱炎患者血清HLA-B27、BALP、CD14水平与病程和骨代谢指标[I型胶原羧基末端肽(ICTP)、Ⅰ型前胶原羧基端肽(PICP)及骨钙素(BGP)]的相关性。结果观察组HLA-B27阳性率及血清BALP、CD14、ICTP、PICP、BGP水平显著高于对照组,差异有统计学意义(P<0.05)。观察组早期、中期、晚期患者HLA-B27、BALP、CD14水平比较差异有统计学意义(P<0.05)。观察组早期、中期、晚期患者ICTP、PICP、BGP水平比较差异有统计学意义(P<0.05)。随着患者疾病的进展,血清BALP、ICTP、PICP、BGP水平呈现显著升高,差异有统计学意义(P<0.05)。患者HLA-B27、BALP、CD14水平与病程骨代谢水平呈现正相关。结论临床可依据强直性脊柱炎患者HLA-B27、BALP、CD14水平以及骨代谢水平对患者的疾病进展情况进行评估。Objective To study the relationship between the serum levels of human leukocyte antigen B27(HLA-B27), bone alkaline phosphatase(BALP) and soluble CD14(CD14) and disease course and bone metabolism indexes in patients with ankylosing spondylitis. Methods Sixty patients with ankylosing spondylitis who were treated at the First Affiliated Hospital of Xinxiang Medical College from April 2020 to December 2022 were selected as the observation group.Another 60 healthy examinees from our hospital during the same period were selected as the control group. The patients in the observation group were divided into early 28 cases, middle 21 cases, and the late 11 cases according to the progress of the disease. The levels of HLA-B27, BALP, and CD14 between the two groups were compared, and the relationship between HLA-B27, BALP, and CD14 levels and disease course and bone metabolism indexes[type I collagen carboxy terminal peptide(ICTP), type I procollagen carboxy terminal peptide(PICP), and osteocalcin(BGP)] were studied. Results The positive rate of HLA-B27 and the levels of serum BALP, CD14, ICTP, PICP, and BGP in the observation group were significantly higher than those in the control group, with significant differences(P<0.05).There were significant differences in the levels of HLA-B27, BALP, and CD14 among early, middle, and late patients in the observation group(P<0.05).There were significant differences in the levels of ICTP, PICP, and BGP among early, middle, and late patients in the observation group(P<0.05). It was found that with the progression of the disease, the serum levels of BALP, ICTP, PICP and BGP were significantly increased, and the differences were significant(P<0.05). The levels of HLA-B27, BALP and CD14 were positively correlated with disease course and bone metabolism levels.Conclusions The levels of HLA-B27, BALP, CD14 and bone metabolism indexes can be used to evaluate the progress of the disease.

关 键 词：强直性脊柱炎 人类白细胞抗原B27 骨碱性磷酸酶 人可溶性CD14 骨代谢 

分 类 号：R593.23[医药卫生—内科学]