雷火灸联合运腹通经推拿法治疗寒湿型盆腔炎患者的临床疗效及对其前列腺素F2α、神经生长因子血清表达的影响  

The Clinical Effect of Thunder-fire Moxibustion Combined with Yunfu Tongjing Massage in the Treatment of Patients with Cold-dampness Type Pelvic Inflammatory Disease and Their Impact on the Serum Expression of Prostaglandin F2αand Nerve Growth Factor

作　　者：曹玲君[1] 崔树娜 程燕[1] 丁娜[3] 张园曼 Cao Ling-jun;Cui Shu-na;Cheng Yan;Ding Na;Zhang Yuan-man(Department of TCM Gynecology,Yangzhou Maternal and Child Health Hospital,Yangzhou Jiangsu 225002;Department of Integrative Chinese and Western Medicine,School of Medicine of Yangzhou University,Yangzhou Jiangsu 225000;Department of TCM,Yangzhou Maternal and Child Health Hospital,Yangzhou Jiangsu 225002)

机构地区：[1]扬州市妇幼保健院中医妇科,江苏扬州225002 [2]扬州大学附属医院妇产科,江苏扬州225000 [3]扬州市妇幼保健院中医科,江苏扬州225002

出　　处：《世界中西医结合杂志》2023年第12期2488-2492,2497,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：江苏省高等学校基础科学项目(21KJA360004)。

摘　　要：目的探究雷火灸联合运腹通经推拿法治疗寒湿型盆腔炎患者的临床疗效及对其神经生长因子(Nerve growth factor,NGF)、前列腺素F2α(Prostaglandin F2α,PGF2α)血清表达的影响。方法选取2021年1月—2022年12月期间扬州市妇幼保健院收治的盆腔炎患者90例作为研究对象,按随机数字表法分为对照组和研究组,每组各45例。对照组采取常规西医治疗,研究组在对照组基础上采取雷火灸及运腹通经推拿法。治疗3个月经周期后,观察比较两组患者临床疗效、不良反应情况,治疗前后中医证候积分、炎症反应指标[C反应蛋白(C-reactive protein,CRP)、降钙素原(Procalcitonin,PCT)、中性粒细胞、白细胞计数]水平、疼痛指标(NGF、PGF2α)水平。结果治疗后研究组临床总有效率93.33%(42/45)明显高于对照组77.78%(35/45),差异有统计学意义(P<0.05)。治疗后两组患者带下量多、腰骶胀痛/冷痛、下腹胀痛伴有冷感及月经异常、形寒肢冷、经行腹痛加剧分值均较治疗前降低,差异有统计学意义(P<0.05);且研究组中医证候积分低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清CRP、PCT、中性粒细胞、白细胞计数均较治疗前降低,差异有统计学意义(P<0.05);且研究组血清CRP、PCT、中性粒细胞、白细胞计数均低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清NGF、PGF2α水平较治疗前降低,差异有统计学意义(P<0.05);且研究组血清NGF、PGF2α水平均低于对照组,差异有统计学意义(P<0.05)。治疗期间,研究组不良反应发生率8.89%与对照组6.67%比较,差异无统计学意义(P>0.05)。结论采取雷火灸联合运腹通经推拿法对寒湿型盆腔炎患者实施干预,可有效缓解临床症状,减轻炎症反应及疼痛反应程度,提升治疗效果,且安全性具有保证。Objective To explore the clinical effect of thunder-fire moxibustion combined with Yunfu Tongjing massage in the treatment of patients with cold-dampness type pelvic inflammatory disease and their impact on the serum expression of nerve growth factor(NGF)and prostaglandin F2α(PGF2α).Methods Ninety patients with pelvic inflammatory disease admitted to Yangzhou Maternal and Child Health Hospital from January 2021 to December 2022 were selected and assigned into a control group and a study group according to random number table method,45 cases in each group.Conventional Western medicine was used in the control group,and thunder-fire moxibustion combined with Yunfu Tongjing massage based on the control group were applied in the study group.After the treatment for 3 menstrual cycles,the clinical effect and adverse reactions in the two groups were observed;the Traditional Chinese Medicine(TCM)syndrome scores,inflammatory response indicators[C-reactive protein(CRP),procalcitonin(PCT),neutrophil and white blood cell counts],and the pain indicators(NGF,PGF2α)before and after treatment were compared between the two groups.Results The total clinical effective rate in the study group after treatment was 93.33%(42/45),which was significantly higher than that in the control group 77.78%(35/45),and the difference was statistically significant(P<0.05).The scores of higher leucorrhea volume,lumbosacral swelling pain/cold pain,lower abdominal swelling pain accompanied by cold sensation and abnormal menstruation,feeling cold and limb cold,and abdominal pain exacerbation during menstruation after treatment were lower than those before treatment in both the two groups,with statistical significance(P<0.05),and the TCM syndrome score in the study group was lower than that in the control group,with statistical significance(P<0.05).The serum CRP,PCT,neutrophil and white blood cell counts of the patients in both the two groups after treatment were lower than those before treatment,and the difference was statistically significant(P<0.05

关 键 词：雷火灸 运腹通经推拿法 寒湿型盆腔炎 神经生长因子 前列腺素F2Α 

分 类 号：R245.31[医药卫生—针灸推拿学]