小胶质细胞在HIV-1感染中作用研究进展  

Research progress on the role of microglia in HIV-1 infection

作　　者：魏伟 苏布敦格日乐 佟丽秋 WEI Wei;Subudungerile;TONG Liqiu(Hulunbuir Center for Disease Control and Prevention,Hulunbuir 021008,Inner Mongolia Autonomous Region,China)

机构地区：[1]呼伦贝尔市疾病预防控制中心,内蒙古自治区呼伦贝尔021008

出　　处：《中国艾滋病性病》2023年第12期1366-1370,共5页Chinese Journal of Aids & STD

基　　金：呼伦贝尔地区HIV流行特征及HIV感染趋势预测模型研究(SF2023008)。

摘　　要：虽然ART能够抑制病毒复制,但由于HIV整合在宿主细胞的基因组中,难以被根治。小胶质细胞是中枢神经系统重要的免疫细胞,近年来研究发现其可作为中枢神经系统(CNS)病毒储存库,导致HIV不断复制。本文综述了小胶质细胞的生物学特征、在HIV-1感染中的作用及治疗策略的研究进展,旨在为HIV-1治疗提供有效的新的思路。While antiretroviral therapy(ART)can impede viral replication,it is difficult to eradicate HIV due to its integration into the genome of host cells.Microglia are important immune cells in the central nervous system(CNS).Recent findings suggest that microglia may serve as a CNS virus reservoir,leading to ongoing HIV replication.This article reviews the biological characteristics of microglia,as well as their role in HIV-1 infection and research progress for treatment procedures,aiming to provide effective novel ideas for HIV-1 treatment.

关 键 词：小胶质细胞 高效抗反转录病毒疗法 1型艾滋病病毒 神经炎症 艾滋病病毒相关神经认知障碍 

分 类 号：R373.9[医药卫生—病原生物学] R512.91[医药卫生—基础医学]