中医药防治高原病研究现状及趋势的可视化分析  

Visual analysis of studies on traditional Chinese medicine for prevention and treatment of highaltitude disease

作　　者：伍振辉 徐焕华 王一豪 涂博丹 汤响林 李茂星 高月 WU Zhenhui;XU Huanhua;WANG Yihao;TU Bodan;TANG Xianglin;LI Maoxing;GAO Yue(School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang,Jiangxi 330000,China;Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]江西中医药大学药学院,江西南昌330000 [2]军事科学院军事医学研究院辐射医学研究所,北京100850

出　　处：《环境与职业医学》2023年第11期1297-1306,共10页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金项目(82204774)。

摘　　要：[背景]高原环境对进驻高原人群的生理和心理应激产生严重影响,尤其是对高原驻训士兵和高原作业者,寻找防治高原特殊环境损伤药物的需求迫切。[目的]分析中医药防治高原病领域的国内外研究现状、热点及发展趋势,为高原缺氧环境相关疾病的治疗及药物研究提供参考。[方法]检索科学引文数据库及中国知网收录的自建库至2022年中医药防治高原病研究文献。采用Excel、CiteSpace、VOSviewer及RStudio软件对文献发文量、文献类型、发表期刊、作者、研究机构及关键词等进行可视化分析。[结果]共纳入中文文献443篇,英文文献58篇。年发文量总体呈上升趋势。中、英文文献发文量最多的作者分别为马慧萍(37篇)、ZHANG Yi和MENG Xianli(均为8篇)。中、英文文献发文量最多的机构分别为中国人民解放军联勤保障部队第九四〇医院、原兰州军区兰州总医院(32篇)和Chengdu University of Traditional Chinese Medicine(8篇)。发文量最多的中英文期刊分别为《高原医学杂志》(39篇)和Journal of Ethnopharmacology(10篇)。中英文被引最多的文献分别为《红景天对高原人体运动后自由基和血清肌酸激酶的影响》(61次引用)和Anti-hypoxic activity at simulated high altitude was isolated in petroleum ether extract of Saussurea involucrata(68次引用)。中英文文献关键词词频最多的分别为高原红细胞增多症与oxidative stress。关键词时区图与突现图谱显示,该领域研究热点从高原病预防治疗到动物实验研究,再到作用机制研究转变,其中氧化应激、缺氧损伤、炎症反应及细胞凋亡等作为机制研究的重点。[结论]中医药防治高原病领域研究由早期临床疗效观察研究逐渐发展为临床疗效变化与药理作用机制相关联,且基础研究结合多组学技术,以中药复方配伍及单味中药有效成分为着眼点,探究中药药效物质基础及作用机制,从而阐述�[Background]Plateau environment may pose a serious impact on the physiological and psychological stress of people stationed on a plateau,especially for those engaged in military training and occupational activities.There is an urgent need to find drugs to prevent and treat injuries caused by high-altitude environment.[Objective]To analyze the current status,hotspots,and future trends of domestic and international research in the field of prevention and treatment of high-altitude disease(HAD)by traditional Chinese medicine(TCM),and provide references for scientific research.[Methods]Web of Science Core Collection(WOSCC)and China National Knowledge Infrastructure(CNKI)were searched for literature on TCM and HAD published from inception to 2022.Excel,CiteSpace,VOSviewer,and RStudio softwares were used to conduct visual analysis on the number of publications,types of publications,

关 键 词：高原病 高原缺氧环境 中医药 文献计量学 可视化分析 

分 类 号：R12[医药卫生—环境卫生学]