大鼠磁感应热疗的线圈设计与仿真分析  

Coil design and simulation analysis of magnetic induction hyperthermia in rats

作　　者：郭思玮 逯迈 GUO Siwei;LU Mai(Key Lab of Optoelectronic Technology and Intelligent Control of Ministry of Education,Lanzhou Jiaotong University,Lanzhou 730000,China)

机构地区：[1]兰州交通大学光电技术与智能控制教育部重点实验室,甘肃兰州730000

出　　处：《中国医学物理学杂志》2024年第1期101-108,共8页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(51567015,51867014)。

摘　　要：选用亥姆霍兹线圈作为交变磁场发生装置,以大鼠脑部肿瘤为研究对象,建立相关模型,以Pennes生物传热方程为基础,在COMSOL仿真软件中进行电磁场分布和温度场分布计算,并分析影响磁感应热疗结果的因素。结果表明,大鼠肿瘤治疗区域磁场分布均匀,中心磁感应强度为12.847 mT,能达到进行磁感应热疗的条件;温度场分布符合要求,肿瘤区域升温明显,肿瘤中心温度可达46℃以上,肿瘤组织基本能达到治疗温度,能实现比较充分的治疗;线圈匝数、电流、半径及间距、磁场频率等参数均能影响磁感应热疗的效果。本研究结果可为磁感应热疗的临床应用和设备中的线圈设计提供参考。A Helmholtz coil is selected to generate the alternating magnetic field,and the relevant model is established with a rat brain tumor as the research object.Based on the Pennes bioheat transfer equation,the electromagnetic field distribution and temperature field distribution are calculated in COMSOL simulation software,and the factors affecting the outcome of magnetic induction hyperthermia are analyzed.The results show that both magnetic field distribution and temperature field distribution meet the requirements for magnetic induction hyperthermia.The magnetic field distribution in the tumor treatment area is uniform,and the central magnetic induction strength is 12.847 mT.The temperature rise in the tumor area is significant,and the temperature at the tumor center is 46℃ or above,basically reaching the treatment temperature.The therapeutic efficacy of magnetic induction hyperthermia is affected by the number of turns,current,radius and spacing,magnetic field frequency and other parameters.The study provides reference for the clinical application of magnetic induction hyperthermia and the coil design.

关 键 词：磁感应热疗 线圈 耦合场 大鼠模型 

分 类 号：R318[医药卫生—生物医学工程] R730.59[医药卫生—基础医学]