玻璃酸钠联合塞来昔布用于膝骨关节炎射频术后临床评价  

Clinical Evaluation of Sodium Hyaluronate Combined with Celecoxib for Radiofrequency Postoperative Treatment in Patients with Knee Osteoarthritis

作　　者：赵瑞豪 申学红 李通华 ZHAO Ruihao;SHEN Xuehong;LI Tonghua(The People's Hospital of Lincheng County,Xingtai,Hebei,China 054300)

机构地区：[1]河北省邢台市临城县人民医院,河北邢台054300

出　　处：《中国药业》2024年第2期97-100,共4页China Pharmaceuticals

基　　金：河北省卫生健康委科研基金项目[20221599]。

摘　　要：目的探讨玻璃酸钠联合塞来昔布用于膝骨关节炎(KOA)患者射频术后的临床疗效。方法选取医院2020年10月至2022年1月收治的行射频术的KOA患者108例,按治疗方案的不同分为对照组和观察组,各54例。两组患者均于射频术后第1天起口服塞来昔布胶囊,观察组患者加予膝眼关节腔内注射玻璃酸钠注射液。两组均连续用药5周,随访6个月。结果观察组总有效率为94.44%,显著高于对照组的79.63%(P<0.05)。治疗后,观察组患者的P物质、β-内啡肽、神经肽Y、5-羟色胺和前列腺素E2水平,以及肿瘤坏死因子-α、类风湿因子和白细胞介素6水平均显著低于对照组(P<0.05);治疗后1个月、3个月、6个月,观察组患者的美国特种外科医院(HSS)评分量表得分均显著高于对照组(P<0.05)。结论玻璃酸钠联合塞来昔布用于KOA患者射频术后,能有效提高临床疗效,降低疼痛介质和炎性因子水平,改善患者的疼痛程度和膝关节功能。Objective To investigate the clinical efficacy of sodium hyaluronate combined with celecoxib for radiofrequency postoperative treatment in patients with knee osteoarthritis(KOA).Methods A total of 108 KOA patients underwent the radiofrequency operation in the hospital from October 2020 to January 2022 were selected and divided into the control group and the observation group based on the different treatment regimens,with 54 cases in each group.The patients in the two groups were treated with Celecoxib Capsules orally from the first day after radiofrequency operation,on this basis,the patients in the observation group were treated with intra-articular(knee eyes)injection of Sodium Hyaluronate Injection.Both groups were treated continuously for five weeks and followed up for six months.Results The total effective rate in the observation group was 94.44%,which was significantly higher than 79.63%in the control group(P<0.05).After treatment,the substance P(SP),β-endorphin(β-EP),neuropeptide Y(NPY),5-hydroxytryptamine(5-HT),prostaglandin E2(PGE2),tumor necrosis factor-α(TNF-α),rheumatoid factor(RF)and interleukin-6(IL-6)levels in the observation group were significantly lower than those in the control group(P<0.05).After one,three and six months of treatment,the Hospital for Special Surgery(HSS)score in the observation group was significantly higher than that in the control group(P<0.05).Conclusion Sodium hyaluronate combined with celecoxib for radiofrequency postoperative treatment in patients with KOA can improve the clinical efficacy,decrease the levels of pain mediators and inflammatory factors,and improve the pain degree and knee joint function of patients.

关 键 词：关节腔内注射 玻璃酸钠 塞来昔布 膝骨关节炎 射频手术 临床疗效 疼痛介质 炎性因子 

分 类 号：R969.4[医药卫生—药理学]