基于葡萄糖激酶的功能探讨从“郁”论治2型糖尿病  

Treatment of Diabetes Mellitus Type 2 from Perspective of"Depression"Based on Function of Glucokinase

作　　者：王孟龙[1] 王彤瑞 陈雪莹 谷峰[1] WANG Menglong;WANG Tongrui;CHEN Xueying;GU Feng(Liaoning University of Trditional Chinese Medicine,Shenyang Liaoning China 110847;The Second Affiliated Hospital to Liaoning University of Trditional Chinese Medicine,Shenyang Liaoning China 110034)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属第二医院,辽宁沈阳110034

出　　处：《中医学报》2024年第2期282-285,共4页Acta Chinese Medicine

基　　金：国家中医药管理局第四批优秀人才(中医基础类)研修项目(10010244B10038)。

摘　　要：葡萄糖激酶分布在肝、脾中,当其功能下降,肝脾功能也随之下降,导致木郁土壅,精微不得布散,郁积于人体血脉脏腑,故木郁土壅是2型糖尿病发病的核心因素。随着“郁”的加重,出现土木之气衰败,肝脾之精“泄而不得藏”,进而“糖郁体内”,导致2型糖尿病发病加重。临证时,应以“木郁达之,土郁夺之”为治疗大法,使脾散精的功能恢复,则多余的糖重新通过脾的散精功能成为营养物质而被人体利用,并在肝藏血的作用下重新合成糖原,则糖尿病自可解除。Glucokinase is distributed in the Liver and Spleen.When its function decreases,the function of the Liver and Spleen also decreases,leading to the Qi stagnation of Wood and Earth,and the Essence can not be dispersed but accumulated in the blood vessels as well as the Zang and Fu organs of the human body.Therefore,the stagnation of Wood and Earth is the core factor for the onset of diabetes mellitus type 2(T2DM).With the aggravation of"depression",the Qi of Wood and Earth declines,and the Essence of Liver and Spleen would"leak yet not be hidden inside",which leads to"depression of sugar in the body",leading to the aggravation of T2DM.At the time of clinical diagnosis and treatment,we should take the method of"relieving the Qi stagnation of Wood and Earth"to restore the function of Spleen Essence dispersing,so that the excess sugar can be used by the human body again through the function of Spleen Essence dispersing,and the glycogen can be synthesized again under the function of Liver storing blood,so that diabetes can be relieved.

关 键 词：2型糖尿病 从“郁”论治 葡萄糖激酶 木郁土壅 

分 类 号：R255.4[医药卫生—中医内科学]