中医药调控自身免疫性皮肤病调节性T细胞的研究进展  

Research Progress on Regulation of Regulatory T Cells in Autoimmune Skin Diseases with Traditional Chinese Medicine

作　　者：冯霞 李阳梅 陈若曦 赵一丁 姜姗姗 FENG Xia;LI Yangmei;CHEN Ruoxi;ZHAO Yiding;JIANG Shanshan(Shaanxi University of Chinese Medicine,Xianyang Shaanxi China 712046;Shaanxi Provincial Hospital of Chinese Medicine,Xi′an Shaanxi China 710003)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西省中医医院,陕西西安710003

出　　处：《中医学报》2024年第2期325-333,共9页Acta Chinese Medicine

基　　金：国家自然科学基金项目(82274537);陕西省重点产业链项目(2021ZDLSF04-12);陕西省中医药管理局课题项目(SZY-KJCYC-2023-005)。

摘　　要：调节性T细胞(regulatory T cells,Treg)在自身免疫性皮肤病的发生发展中起着关键作用,Treg细胞数量减少、功能缺失、相关细胞因子表达异常均与银屑病、系统性红斑狼疮、特应性皮炎等自身免疫性皮肤病密切相关。单味中药、中药单体化合物、中药复方制剂均可调控Treg细胞防治自身免疫性皮肤病,临床疗效显著且安全性较高,主要作用机制为上调Treg细胞数量,增强抑制能力,促进免疫稳态恢复;升高Treg细胞转录因子的表达水平,调控Treg细胞分化;增加IL-10、IL-35等Treg细胞分泌的相关细胞因子的表达,减轻炎症反应。目前,中医药干预研究以内治法为主,有待加强中医外治法干预的研究,且中医药干预Treg细胞多为调节细胞数量、细胞因子及转录因子等,亟需明确其具体作用机制及信号传导通路,为中医药临床治疗此类难治性、复杂性皮肤病提供理论依据。Regulatory T cells(Treg)play a crucial role in the occurrence and development of autoimmune skin diseases.The decrease in Treg cell count,functional deficiency,and abnormal expression of related cytokines are closely related to autoimmune skin diseases such as psoriasis,systemic lupus erythematosus,and atopic dermatitis.Single traditional Chinese medicine,single compound of traditional Chinese medicine,and compound preparations of traditional Chinese medicine can regulate Treg cells in the prevention and treatment of autoimmune skin diseases,with significant clinical efficacy and high safety.The main mechanism of action is to upregulate the number of Treg cells,enhance inhibitory ability,and promote the recovery of immune homeostasis;Elevate the expression level of transcription factors in Treg cells and regulate their differentiation;Increase the expression of cytokines secreted by Treg cells such as IL-10 and IL-35,and alleviate inflammatory response.At present,research on traditional Chinese medicine intervention mainly focuses on internal treatment methods,and there is a need to strengthen research on external treatment methods of traditional Chinese medicine intervention.Moreover,traditional Chinese medicine intervention in Treg cells mainly regulates cell quantity,cytokines,and transcription factors.It is urgent to clarify its specific mechanism of action and signal transduction pathways,providing a theoretical basis for the clinical treatment of such difficult to treat and complex skin diseases with traditional Chinese medicine.

关 键 词：自身免疫性皮肤病 调节性T细胞 中医药 银屑病 系统性红斑狼疮 特应性皮炎 白癜风 斑秃 

分 类 号：R275.9[医药卫生—中西医结合]