鳖甲煎丸治疗肝纤维化  

Treatment of Liver Fibrosis with Biejiajian Pill

作　　者：王飞[1] 陈宝根[1] WANG Fei;CHEN Baogen(The First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中医学报》2024年第2期437-439,共3页Acta Chinese Medicine

基　　金：河南省中医管理局国家中医临床研究基地科研专项基金项目(2018JDZX045)。

摘　　要：目的:观察鳖甲煎丸治疗肝纤维化的临床疗效,并分析脉冲辐射力成像技术(acoustic radiation force impulse,ARFI)评价其防治肝纤维化的客观性。方法:62例S2—S4期肝纤维化患者给予鳖甲煎丸,采用ARFI测定治疗前、治疗3个月、治疗6个月的肝纤维化弹性值,同时与患者3个时期的肝纤维化四项检测结果进行相关性分析。结果:(1)口服鳖甲煎丸治疗前、治疗3个月、治疗6个月的血清学指标比较,差异均有统计学意义(P<0.05)。(2)口服鳖甲煎丸治疗前、治疗3个月、治疗6个月声触诊组织量化(virtual touch tissues quantification,VTQ)值分别为2.06±0.03、1.88±0.05、1.53±0.02,差异均有统计学意义(P<0.01)。(3)口服鳖甲煎丸治疗前、治疗3个月、治疗6个月血清学指标与VTQ值进行相关性分析,VTQ值与透明质酸呈显著相关(P<0.001),与Ⅲ型前胶原、Ⅳ型胶原、层粘连蛋白呈弱相关(P<0.05)。结论:鳖甲煎丸治疗肝纤维化疗效显著,ARFI可评价鳖甲煎丸防治肝纤维化客观疗效。Objective:To observe the clinical efficacy of Biejiajian Pill in treating liver fibrosis and analyze the objectivity of pulse radiation force imaging(ARFI)technology in evaluating its prevention and treatment of liver fibrosis.Method:62 patients with S2-S4 stage liver fibrosis were treated with Biejiajian Pill,and the liver fibrosis elasticity values before treatment,3 months of treatment,and 6 months of treatment were measured using ARFI.At the same time,correlation analysis was conducted on the four detection results of liver fibrosis in the three periods of patients.Results:(1)There were statistically significant differences(P<0.05)in the serological indicators before treatment,3 months after treatment,and 6 months after treatment with oral Biejiajian Pill.(2)The virtual touch tissue quantification(VTQ)values before treatment,3 months after treatment,and 6 months after treatment were 2.06±0.03,1.88±0.05,and 1.53±0.02,respectively,with statistically significant differences(P<0.01).(3)The correlation analysis between serum indicators and ARFI was conducted before treatment,3 months after treatment,and 6 months after treatment with oral Biejia decoction Pills.The VTQ value was significantly correlated with hyaluronic acid(P<0.01),and weakly correlated with typeⅣcollagen,typeⅢprocollagen,and laminin(P<0.05).Conclusion:Biejiajian Pill has a significant therapeutic effect on liver fibrosis,and ARFI can be used to evaluate the objective efficacy of Biejiajian Pill in preventing and treating liver fibrosis.

关 键 词：肝纤维化 鳖甲煎丸 脉冲辐射力成像技术 

分 类 号：R259.752[医药卫生—中西医结合]