血小板相关抗体在儿童免疫性血小板减少症治疗效果评估中的临床价值  

Clinical Value of Platelet Associated Antibodies in Evaluating the Therapeutic Effect on Children with Immune Thrombocytopenia

作　　者：刘娜[1] 白涛敏[1] 李瑞 韩田田[1] 马芳芳 林博浩 LIU Na;BAI Taomin;LI Rui(Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China)

机构地区：[1]陕西省人民医院儿科,陕西西安710068

出　　处：《河北医学》2024年第1期80-83,共4页Hebei Medicine

基　　金：陕西省重点研发项目,(编号:2017SF-239)。

摘　　要：目的:探究血小板相关抗体(PA-Ig)在儿童免疫性血小板减少症(ITP)治疗效果评估中的临床价值。方法:选取2020年2月至2023年2月医院收治的104例ITP患儿以及22例健康儿童作为研究对象,分别将其纳入观察组与对照组,观察组患儿根据治疗结果分为完全反应组、有效组与无效组,所有儿童均进行PA-Ig水平检测。结果:观察组104例患儿中,有85例(81.73%)患儿治疗后为完全反应(完全反应组),11例(10.58%)为有效(有效组),其余8例(7.69%)为无效(无效组);观察组PA-IgG、PA-IgM、PA-IgA水平高于对照组(P<0.05);完全反应组PA-IgG、PA-IgM、PA-IgA水平低于有效组与无效组,有效组PA-IgG、PA-IgM、PA-IgA水平低于无效组,不同治疗效果的三组ITP患儿PA-IgG、PA-IgM、PA-IgA水平比较差异有统计学意义(P<0.05)。结论:对ITP患儿PA-Ig水平进行检测有利于临床针对患儿情况进行治疗与早期疗效评估,降低患儿治疗风险,在ITP患儿治疗效果评估中具有一定评估价值。Objective:To investigate the clinical value of platelet associated antibodies(PA-Ig)in evaluating the therapeutic effect on children with immune thrombocytopenia(ITP).Methods:A study from February 2020 to February 2023 was conducted.104 children with ITP(observation group)and 22 healthy children(control group)were selected as the study subjects.Children in the observation group were divided into the complete response group,the effective group,and the ineffective group based on the treatment outcomes.All children were tested for PA-Ig levels.Results:Among the 104 children in the observation group,85(81.73%)achieved complete response(complete response group),11(10.58%)showed effectiveness(effective group),and the remaining 8(7.69%)were ineffective(ineffective group).PA-IgG,PA-IgM,and PA-IgA levels in the observation group were lower than those in the control group(P<0.05).In the complete response group,PA-IgG,PA-IgM,and PA-IgA levels were lower than in the effective and ineffective groups.The effective group had lower levels compared to the ineffective group.There were statistically significant differences in PA-IgG,PA-IgM,and PA-IgA levels among the three groups with different treatment outcomes(P<0.05).Conclusion:Testing PA-Ig levels in pediatric ITP patients is beneficial for tailor-ing treatment and assessing early efficacy,reducing the risk of treatment,and has certain value in the evalua-tion of treatment outcomes in pediatric ITP patients.

关 键 词：免疫性血小板减少症 血小板相关抗体 儿童 治疗效果 

分 类 号：R725.5[医药卫生—儿科]