支气管扩张合并NTM病患者外周血免疫指标谱水平分析  

Analysis of Peripheral Blood Immune Indices in Patients with Bronchiectasis Complicated by NTM Infection

作　　者：梅益枝 姚超 张毕玲 MEI Yizhi;YAO Chao;ZHANG Biling(Anhui Chest Hospital,Anhui Hefei 230022,China)

机构地区：[1]安徽省胸科医院结核六科,安徽合肥230022

出　　处：《河北医学》2024年第1期98-102,共5页Hebei Medicine

基　　金：安徽省自然科学基金项目,(编号:2208085MH193)。

摘　　要：目的:分析支气管扩张合并非结核分枝杆菌(NTM)病患者外周血免疫指标谱水平。方法:选取2021年5月至2023年5月我院收治的96例支气管扩张患者,根据患者是否合并NTM感染分为感染组(33例)和未感染组(63例),感染组依据支气管扩张受累肺叶数分为1~2肺叶组(11例)、3~4肺叶组(12例)、5~6肺叶组(10例)。比较各组患者外周血免疫球蛋白、T淋巴细胞亚群、超敏C-反应蛋白(hs-CRP)、胱抑素C(CysC)、同型半胱氨酸(Hcy)水平。结果:两组外周血免疫球蛋白水平比较,差异无统计学意义(P>0.05),感染组外周血CD3^(+)、CD4^(+)低于未感染组(P<0.05),感染组CD8^(+)高于未感染组(P<0.05);两组外周血Hcy比较,差异无统计学意义(P>0.05),感染组hs-CRP、CysC水平高于未感染组(P<0.05);三组不同受累肺叶数目患者外周血IgA、IgM、IgG、CD8^(+)比较,差异无统计学意义(P>0.05),三组不同受累肺叶数目患者CD3^(+)、CD4^(+)比较,1~2肺叶组>3~4肺叶组>5~6肺叶组(P<0.05);三组外周血hs-CRP、CysC及Hcy水平对比,差异无统计学意义(P>0.05)。结论:支气管扩张合并NTM病患者外周血CD3^(+)、CD4^(+)降低,CD8^(+)、hs-CRP、CysC升高,且CD3^(+)、CD4^(+)水平与受累肺叶数相关。Objective:To analyze the level of peripheral blood immune spectrum in patients with bronchiectasis complicated with nontuberculous Mycobacterium(NTM).Methods:Ninety-six patients with bronchiectasis admitted to our hospital from May 2021 to May 2023 were selected.The patients were divided into an infection group(33 cases)and a non-infection group(63 cases)based on whether NTM infection was present.In the infection group,patients were further categorized based on the number of lung lobes affected by bronchiectasis:1~2 lobes group(11 cases),3~4 lobes group(12 cases),and 5~6 lobes group(10 cases).Peripheral blood levels of immunoglobulins,T lymphocyte subsets,high-sensitivity C-reactive protein(hs-CRP),cystatin C(CysC),and homocysteine(Hcy)were compared between the groups.Results:There was no significant difference in the levels of peripheral blood immunoglobulins between the two groups(P>0.05).The peripheral blood CD3^(+)and CD4^(+)levels were lower,and CD8^(+)levels were higher in the infection group compared to the non-infection group(P<0.05).There was no significant difference in peripheral blood Hcy levels between the two groups(P>0.05).However,hs-CRP and CysC levels were higher in the infection group than in the non-infection group(P<0.05).When comparing different groups based on the number of affected lung lobes,there was no significant difference in peripheral blood IgA,IgM,IgG,CD8^(+)levels(P>0.05).However,the CD3^(+)and CD4^(+)levels showed a decreasing trend from the 1~2 lobes group to the 5~6 lobes group(P<0.05).There was no significant difference in peripheral blood hs-CRP,CysC,and Hcy levels among the three groups(P>0.05).Conclusion:In patients with bronchiectasis complicated by NTM infection,peripheral blood CD3^(+)and CD4^(+)levels are decreased,CD8^(+),hs-CRP,and CysC levels are increased.Furthermore,CD3^(+)and CD4^(+)levels are correlated with the number of affected lung lobes.

关 键 词：支气管扩张 非结核分枝杆菌 免疫球蛋白 T淋巴细胞亚群 超敏C-反应蛋白 胱抑素C 

分 类 号：R562.22[医药卫生—呼吸系统]