脂毒性致糖尿病肾病肾小球滤过屏障损伤机制研究进展  

Research progress on the mechanism of damage of diabetic kidney disease glomerular filtration barrier caused by lipotoxicity

作　　者：宋开永 熊维建[1] 田璐 熊梦缘 陶文强[1] 王淼 SONG Kaiyong;XIONG Weijian;TIAN Lu;XIONG Mengyuan;TAO Wenqiang;WANG Miao(Department of Nephropathy,Chongqing Hospital of Traditional Chinese Medicine,Chongqing400010,China;Department of Gastroenterology,Huanggang Traditional Chinese Medicine Hospital,Hubei Province,Huanggang438000,China)

机构地区：[1]重庆市中医院肾病科,重庆400010 [2]湖北省黄冈市中医院消化内科,湖北黄冈438000

出　　处：《中国医药导报》2023年第34期36-39,共4页China Medical Herald

基　　金：国家自然科学基金青年科学基金资助项目(82104848)。

摘　　要：超过10%的人口都受到肾功能异常的影响,大多数肾脏病的特征是肾小球滤过屏障的破坏。肾小球滤过屏障是一种独特的多层结构,由肾小球内皮细胞、基底膜和足细胞构成。当脂代谢紊乱时,就会诱导P2X7R-NLRP3炎症小体轴及胆固醇调节元件结合蛋白、血管内皮生长因子-B、连接黏附分子样蛋白、类固醇O-酰基转移酶1、三磷酸腺苷结合盒转运体A1编码基因等蛋白酶和因子产生炎症反应、氧化应激。本文重点讨论脂质异位沉积产生的脂毒性对肾小球滤过屏障的影响,为糖尿病肾脏病疗法提供新的思路。More than 10%of the population is affected by abnormal kidney function,and most kidney diseases are characterized by a breakdown of the glomerular filtration barrier.Glomerular filtration barrier is a unique multilayered structure composed of glomerular endothelial cells,basement membrane,and podocytes.When lipid metabolism is disturbed,it will induce P2X7R-NLRP3 inflammatory body axis,sterol-regulatory element binding protein,vascular endothelial growth factor-B,junction adhesion molecule-like protein,sterol-O-acyl transferase 1,ATP-binding cassette transporter A1,and other proteases and factors to produce inflammatory response and oxidative stress.This paper focuses on the effects of lipid toxicity caused by ectopic lipid deposition on glomerular filtration barrier,which will provide a new idea for the treatment of diabetic kidney disease.

关 键 词：脂毒性 肾小球滤过屏障 胆固醇调节元件结合蛋白 血管内皮生长因子-B 类固醇O-酰基转移酶1 三磷酸腺苷结合盒转运体A1编码基因 

分 类 号：R587.2[医药卫生—内分泌]