抗中性粒细胞胞浆抗体相关性小血管炎与感染关系的研究进展  

Research progress on the relationship between anti-neutrophil cytoplasmic antibody-associated vasculitis and infection

作　　者：高畅 马良[1] 苟慎菊[1] GAO Chang;MA Liang;GOU Shenju(Department of Nephrology,West China Hospital of Sichuan University,Sichuan Province,Chengdu 610000,China)

机构地区：[1]四川大学华西医院肾脏内科,四川成都610000

出　　处：《中国医药导报》2023年第34期44-47,52,共5页China Medical Herald

基　　金：四川省科技厅-科技创新人才项目(2020JDRC0022)。

摘　　要：在目前糖皮质激素联合免疫抑制剂的治疗策略下,感染成为抗中性粒细胞胞浆抗体相关性小血管炎(AAV)治疗中主要的并发症及早期死亡的首要原因之一。同时,感染也可以通过多种机制诱发和加重AAV,增加AAV的发病率及复发率。临床实践中,活动期的AAV与感染临床表现相似,容易误诊,需从多个层面、使用多种检测方法区别感染和AAV,做到早诊断、早治疗。随着目前检测手段的不断完善及对病原体深入的认识,将利于进一步理解感染与AAV间的密切关系,为两者临床的鉴别诊断及治疗提供帮助。Under the current treatment strategy of glucocorticoid combined with immunosuppressants,infection has become one of the main complications and early causes of death in the treatment of anti-neutrophil cytoplasmic antibody associated vasculitis(AAV).At the same time,infection can also induce and aggravate AAV through various mechanisms,increasing the incidence and recurrence rate of AAV.In clinical practice,the clinical manifestations of active AAV and infection are similar,and it is easy to be misdiagnosed.It is necessary to distinguish infection and AAV from multiple levels and use multiple detection methods to achieve early diagnosis and treatment.With the continuous improvement of current detection methods and in-depth understanding of pathogens,it will be beneficial to further understand the close relationship between infection and AAV,and provide help for clinical differential diagnosis and treatment of the two.

关 键 词：抗中性粒细胞胞浆抗体相关性血管炎 感染 免疫抑制 机制 

分 类 号：R453.9[医药卫生—治疗学]