荧光纳米探针的合成及其应用研究进展  

Research Progress of Design,Synthesis and Application of Fluo⁃rescent Nanoprobe

作　　者：侯可心 丁晟 杨焜 王在玺 李钒 HOU Ke-xin;DING Sheng;YANG Kun;WANG Zai-xi;LI Fan(Institute of Medical Support Technology,Academy of System Engineering of Academy of Military Sciences,Tianjin 300171,China)

机构地区：[1]军事科学院系统工程研究院,天津300171

出　　处：《分析测试学报》2024年第1期1-18,共18页Journal of Instrumental Analysis

摘　　要：近年来涌现的荧光纳米探针独特的尺寸及结构赋予其优异的光稳定性、较高的荧光量子产率、可调的激发发射波长等众多优势,引起科研工作者的广泛关注。荧光纳米探针作为一类重要的光响应性纳米材料在小分子及生物大分子检测、细胞成像、活体诊断等领域具有广阔的应用前景,有望成为传统有机荧光染料的理想替代物。该文针对目前研究较多的量子点、金属纳米簇及金属-有机框架及其他纳米荧光探针,介绍了其结构组成、物理化学性质等基本性质,并着重阐述其主要合成方法以及在化学传感、生物医学等领域的应用及研究进展,最后对目前该领域的发展前景做出总结及展望。In recent years the unique size and structure of fluorescent nanoprobe would give it excel⁃lent performances including good photo stability,high fluorescence quantum yield and the adjustable length of the excitation and emission wavelengths,and these advantages attract wide attention of re⁃searchers.Fluorescent nanoprobe as an important kind of photo-responsive nanomaterial is consid⁃ered promising in many fields such as small molecules detection,biomacromolecules detection,cel⁃lular imaging and real-time in vivo diagnosis,and is expected to become an ideal substitute for tradi⁃tional organic fluorescent dyes.The aim of this review is to provide a survey on the research progress of the main materials such as quantum dots,metal nanoclusters and metal organic frameworks,in⁃cluding structure and physicochemical property,especially the synthetic method and the application in chemical sensing and biomedical fields,while finally make summary and prospect.

关 键 词：荧光纳米探针 光响应性 量子点 金属纳米簇 金属-有机框架 

分 类 号：O657.3[理学—分析化学] G353.11[理学—化学]