心脏MR组织追踪技术定量评估心肌淀粉样变性患者心肌应变  

Cardiac MR tissue tracking technique for quantitatively evaluating myocardial strain of cardiac amyloidosis patients

作　　者：何江凯 崔晨[1] 马为[2] 王智[2] 刘佳[1] 李玮[1] 赵凯[1] 奈日乐 徐莎莎[1] 邱建星[1] HE Jiangkai;CUI Chen;MA Wei;WANG Zhi;LIU Jia;LI Wei;ZHAO Kai;NAI Rile;XU Shasha;QIU Jianxing(Department of Radiology,Peking University First Hospital,Beijing 100034,China;Department of Cardiovascular,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院医学影像科,北京100034 [2]北京大学第一医院心血管内科,北京100034

出　　处：《中国介入影像与治疗学》2024年第1期42-47,共6页Chinese Journal of Interventional Imaging and Therapy

基　　金：苏州工业园区心馨心血管健康基金会资助ATTR-CM流行病研究基金(2022-CCA-ATTR-CM-019)。

摘　　要：目的观察利用心脏MR组织追踪(CMR-TT)技术定量评估心肌淀粉样变性(CA)患者心肌应变的可行性。方法对20例免疫球蛋白轻链型心肌淀粉样变性(AL-CA,A组)、20例转甲状腺素蛋白型CA(ATTR-CA,B组)患者及20名健康受试者(C组)采集心脏MRI,以CMR-TT技术获得心肌应变参数;比较3组间左心室心功能参数差异,以及左心室各节段及整体心肌应变参数的差异,包括3D纵向应变(LS)、3D径向应变(RS)及3D圆周应变(CS)。结果A、B组左心室心功能参数与C组差异均有统计学意义(P均<0.01),而A与B组间左心室心功能参数差异均无统计学意义(P均>0.05)。除心尖段RS(P=0.81)外,A、B组应变参数均低于C组(P均<0.01),而A与B组间应变参数差异均无统计学意义(P均>0.05)。结论CMR-TT技术可用于定量评估CA患者左心室心肌应变。Objective To observe the feasibility of cardiac MR tissue tracking(CMR-TT)technique for quantitatively evaluating myocardial strain of patients with myocardial amyloidosis(CA).Methods Cardiac MRI were collected from 20 patients of immunoglobulin amyloid light-chain CA(AL-CA,group A),20 cases of transthyretin CA(ATTR-CA,group B)and 20 healthy subjects(group C),and myocardial strain parameters were obtained using CMR-TT technique.Left ventricular cardiac function parameters were compared among 3 groups,so were strain parameters of each myocardial segment of left ventricle and global myocardium,including 3D longitudinal strain(LS),3D radial strain(RS)and 3D circumferential strain(CS).Results Compared with those in group C,significant differences of left ventricular cardiac function parameters were found in both group A and B(all P<0.01),while no statistical difference was found between group A and B(all P>0.05).Except for apical segment RS(P=0.81),strain parameters in group A and B were both lower than those in group C(all P<0.01),while no significant difference was detected between group A and B(all P>0.05).Conclusion CMR-TT technique could be used to quantitatively evaluate left ventricular myocardial strain of CA patients.

关 键 词：心肌 淀粉样变性 磁共振成像 组织追踪技术 

分 类 号：R541[医药卫生—心血管疾病] R445.2[医药卫生—内科学]