纳米粒子技术治疗缺血性心脏病的研究进展  

Research progress of nanoparticles in treatment of ischemic heart disease

作　　者：杨平平 杨丽芳 YANG Ping-ping;YANG Li-fang(Department of Anesthesiology,Xi’an Children Hospital,Xi’an 710003,China)

机构地区：[1]西安市儿童医院麻醉与围术期医学科,陕西省西安市710003

出　　处：《中国心血管病研究》2024年第1期14-19,共6页Chinese Journal of Cardiovascular Research

摘　　要：缺血性心脏病作为常见心脏病,其致残率和死亡率居高不下,严重威胁人类健康,目前的治疗策略为口服药物和手术,但还远不能满足临床需求。纳米粒子作为一种新型治疗技术,通过修饰或负载药物,主动或被动靶向心脏区域的细胞和分子,通过增加药物在特定部位的聚集、生物利用度及半衰期来提高治疗效果。本文对纳米粒子在治疗缺血性心脏病中的文献研究及相关进展进行了总结并综述。As a prevalent heart illness,ischemic heart disease(IHD)poses a severe danger to human health due to its high mortality and disability rates.However existing therapy options of oral medicines and surgery fall well short of clinical demands.As a revolutionary therapeutic technology,nanoparticles actively or passively target cells and molecules in the cardiac area by modifying or loading with drugs to improve therapeutic efficacy by boosting drug aggregation,bioavailability and half-life at specific places.This article reviews the literatures and associated achievements in the treatment of IHD with nanoparticles.

关 键 词：缺血性心脏病 纳米粒子 治疗 动脉粥样硬化 心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]