血压升高与我国中年人群生存时间关系的前瞻性研究  

A prospective study on the relationship between elevated blood pressure and survival time in the middleaged Chinese adults

作　　者：袁坤 黄宜林 张林峰[1] 田野[1] 李莹[1] 赵连成[1] YUAN Kun;HUANG Yi-lin;ZAHNG Lin-feng;TIAN Ye;LI Ying;ZHAO Lian-cheng(Division of P revention and Community Health,Fuwai Hospital and National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100032,China)

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院社区防治部,北京市100032

出　　处：《中国心血管病研究》2024年第1期41-46,共6页Chinese Journal of Cardiovascular Research

基　　金：国家自然科学基金(81973117)。

摘　　要：目的 基于前瞻性队列探讨血压升高对我国中年人群生存时间的影响。方法 1982-1985年在全国10组35~59岁人群中进行心血管病危险因素调查并对死亡结局进行随访。采用生存曲线下面积法计算血压升高人群及非血压升高人群的平均生存时间并进行比较。将收缩压超过115 mmHg定义为血压升高。结果 纳入分析的研究对象共24096人,其中男性12161人,女性11935人,平均随访19.7年。血压升高人群与非血压升高人群相比,在总人群中,生存时间减少0.50岁;在男性人群中,生存时间减少0.46岁;在女性人群中,生存时间减少0.94岁;在城市人群中,生存时间减少0.63岁;在农村人群中,生存时间减少0.61岁;在35~44岁人群中,生存时间减少0.27岁;在45~54岁人群中,生存时间减少0.50岁;在55岁及以上的人群中,生存时间减少0.67岁。结论 血压升高对我国中年人群生存时间的影响女性大于男性,城市大于农村,年龄越大,影响越大。Objective To explore the effect of elevated blood pressure on survival time in the middle-aged Chinese adults based on a prospective cohort study.Methods From 1982 to 1985,a cardiovascular risk factor survey was conducted on 10 groups of subjects aged 35 to 59 across China and the death outcomes were followed up.Elevated blood pressure was defined as systolic blood pressure exceeding 115 mmHg.The area under survival curve method was used to calculate the average survival time of people with and without elevated blood pressure.Results A total of 24096 study subjects were included in the analysis,including 12161 males and 11935 females,with an average follow-up of 19.7 years.Compared with those without elevated blood pressure,the subjects with elevated blood pressure had a 0.50-year reduction in survival time in the total population,a 0.46-year reduction in the male population,a 0.94-year reduction in the female population,a 0.63-year reduction in the urban population,a 0.61-year reduction in the rural population,a 0.27-year reduction in the 35-44-year-old population,a 0.50-year reduction in the 45-54-year-old population and a 0.67-year reduction in the 55-year-old and older population.Conclusion The impact of elevated blood pressure on the survival time of middle-aged Chinese adults is greater for women than men,and greater for those lived in the urban areas than those in the rural areas;and the older the age,the greater the impact.

关 键 词：血压 生存时间 生存曲线下面积 

分 类 号：R544.1[医药卫生—心血管疾病]