地牡宁神口服液联合可乐定透皮贴治疗儿童抽动-秽语综合征效果与安全性研究  

Study on the Efficacy and Safety of Dimu Ningshen Oral Liquid Combined with Clonidine Transdermal Patch in the Treatment of Tourette's Syndrome in Children

作　　者：文伟 肖珊 罗丽 WEN Wei;XIAO Shan;LUO Li(Department of Pharmacy,Ganzhou Maternal and Child Health Hospital,Ganzhou 341000,China;不详)

机构地区：[1]赣州市妇幼保健院药剂科,江西赣州341000 [2]赣南医学院第一附属医院药学部,江西赣州341000

出　　处：《中国医学创新》2024年第1期87-91,共5页Medical Innovation of China

基　　金：赣州市指导性科技计划项目(20222ZDX7548)。

摘　　要：目的:探讨地牡宁神口服液联合可乐定透皮贴治疗儿童抽动-秽语综合征(TS)患儿的效果。方法:选取2021年1月—2022年7月赣州市妇幼保健院收治的60例TS患儿,按随机数字表法分为两组,各30例。对照组给予可乐定透皮贴治疗,观察组加用地牡宁神口服液治疗,均持续6个月。对比两组临床疗效、症状改善时间、血清学指标及安全性。结果:观察组治疗总有效率96.67%,高于对照组的73.33%(P<0.05)。观察组运动性抽动改善时间(1.89±0.34)个月,发声性抽动改善时间(1.95±0.28)个月,综合性损伤症状改善时间(2.04±0.55)个月,均早于对照组的(2.46±0.57)、(2.48±0.61)、(2.78±0.81)个月,差异均有统计学意义(P<0.05)。治疗前两组免疫功能、血清学指标比较,差异均无统计学意义(P>0.05);治疗后观察组血清免疫球蛋白G(IgG)水平为(6.05±0.47)g/L,免疫球蛋白A(IgA)水平为(0.49±0.10)g/L,免疫球蛋白M(IgM)水平为(0.51±0.15)g/L,白细胞介素-12(IL-12)水平为(101.15±8.64)pg/mL,肿瘤坏死因子-α(TNF-α)水平为(177.44±13.60)pg/mL,均低于对照组的(6.52±0.55)g/L、(0.68±0.13)g/L、(0.67±0.14)g/L、(112.74±9.55)pg/L、(202.49±14.68)pg/mL,差异均有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论:地牡宁神口服液联合可乐定透皮贴治疗TS效果显著,可加快症状缓解,促进血清学指标复常,安全有效。Objective:To explore the effect of Dimu Ningshen Oral Liquid combined with Clonidine Transdermal Patch in the treatment of children with Tourette's syndrome(TS).Method:A total of 60 children with TS admitted to Ganzhou Maternal and Child Health Hospital from January 2021 to July 2022 were randomly divided into two groups,with 30 cases each group.The control group was treated with Clonidine Transdermal Patch,and the observation group was added with Dimu Ningshen Oral Liquid,both treated for 6 months.The clinical efficacy,symptom improvement time,serological indexes and safety of the two groups were compared.Result:The total effective rate in the observation group was 96.67%,which was higher than 73.33%in the control group(P<0.05).The improvement time of motor tic(1.89±0.34)months,vocal tic(1.95±0.28)months,and comprehensive injury symptoms(2.04±0.55)months in the observation group,which were earlier than(2.46±0.57),(2.48±0.61)and(2.78±0.81)months in the control group,with statistically significant differences(P<0.05).There were no significant differences in immune function and serological indexes between the two groups before treatment(P>0.05);after treatment,the level of serum immunoglobulin G(IgG)was(6.05±0.47)g/L,the level of immunoglobulin A(IgA)was(0.49±0.10)g/L,the level of immunoglobulin M(IgM)was(0.51±0.15)g/L,the level of interleukin-12(IL-12)was(101.15±8.64)pg/mL,and the level of tumor necrosis factor-α(TNF-α)was(177.44±13.60)pg/mL in the observation group,which were significantly lower than(6.52±0.55)g/L,(0.68±0.13)g/L,(0.67±0.14)g/L,(112.74±9.55)pg/mL,(202.49±14.68)pg/mL in the control group(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion:The combination of Dimu Ningshen Oral Liquid and Clonidine Transdermal Patch is effective in the treatment of TS,which can accelerate the remission of symptoms,promote the normalization of serological indicators,and is safe and effective.

关 键 词：抽动-秽语综合征 地牡宁神口服液 可乐定透皮贴 血清学指标 安全性 

分 类 号：R277.7[医药卫生—中医学]