糠酸莫米松鼻喷雾剂联合阿奇霉素及咽鼓管吹张治疗儿童急性分泌性中耳炎的临床研究  

Study of Mometasone Furoate Nasal Spray Combined with Azithromycin and Eustachian Tube Insufflation in the Treatment of Acute Secretory Otitis Media in Children

作　　者：廖清花 LIAO Qinghua(Department of Pharmacy,Maternity&Child Care Center of Xinyu,Xinyu 338000,China)

机构地区：[1]新余市妇幼保健院药剂科,江西新余338000

出　　处：《中国医学创新》2024年第1期128-131,共4页Medical Innovation of China

摘　　要：目的:探讨糠酸莫米松鼻喷雾剂联合阿奇霉素及咽鼓管吹张对急性分泌性中耳炎(ASOM)患儿的影响。方法:选取2021年8月—2022年7月新余市妇幼保健院收治的84例ASOM患儿,根据随机数字表法分成研究组(42例)与对照组(42例),对照组采用阿奇霉素联合咽鼓管吹张治疗,研究组在对照组基础上联合使用糠酸莫米松鼻喷雾剂治疗,对两组临床疗效、炎症因子、症状缓解时间、复发率及家属疗效满意度进行比较。结果:治疗后,和对照组相比,研究组总有效率更高,差异有统计学意义(P<0.05)。治疗前,两组白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)及降钙素原(PCT)比较,差异均无统计学意义(P>0.05);治疗后,研究组上述指标均低于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组耳痛、听力、耳内堵塞、耳鸣症状缓解时间均短于对照组,差异均有统计学意义(P<0.05)。研究组复发率低于对照组,研究组家属疗效满意度高于对照组,差异均有统计学意义(P<0.05)。结论:糠酸莫米松鼻喷雾剂联合阿奇霉素及咽鼓管吹张应用于儿童ASOM治疗中,可提高临床疗效,降低炎症因子,改善临床症状,减少复发率,提高家属疗效满意度。Objective:To investigate the effect of Mometasone Furoate Nasal Spray combined with Azithromycin and eustachian tube insufflation in the treatment of acute secretory otitis media(ASOM)in children.Method:A total of 84 children with ASOM admitted to Maternity&Child Care Center of Xinyu from August 2021 to July 2022 were selected and divided into the study group(42 cases)and the control group(42 cases)according to the random number table method.The control group was treated with Azithromycin combined with eustachian tube insufflation,and the study group was treated with Mometasone Furoate Nasal Spray on the basis of the control group.The clinical efficacy,inflammatory factors,symptom relief time,recurrence rate and the satisfaction of parents with the curative effect were compared between the two groups.Result:After treatment,the total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in interleukin-1β(IL-1β),interleukin-8(IL-8)and procalcitonin(PCT)between the two groups(P>0.05);after treatment,the above indexes in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the relief time of otalgia,hearing,ear obstruction and tinnitus in the study group were shorter than those in the control group,the differences were statistically significant(P<0.05).The recurrence rate of the study group was lower than that of the control group,and the satisfaction of parents with the curative effect of the study group was higher than that of the control group,the differences were statistically significant(P<0.05).Conclusion:Mometasone Furoate Nasal Spray combined with Azithromycin and eustachian tube insufflation in the treatment of ASOM children can improve the clinical efficacy,reduce inflammatory factors,improve clinical symptoms,reduce the recurrence rate,and improve the satisfaction of parents with the curative effect.

关 键 词：糠酸莫米松鼻喷雾剂 阿奇霉素 咽鼓管吹张 儿童急性分泌性中耳炎 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]