部分泛素特异性蛋白酶生物学功能的研究进展  

Research Progress in Biological Functions of Partial Ubiquitin-specific Proteases

作　　者：杨静 张丽璇 张晨钰 安康[3] YANG Jing;ZHANG Lixuan;ZHANG Chenyu;AN Kang(Basic Medical College of Hebei North University,Zhangjiakou 075000,China;不详)

机构地区：[1]河北北方学院基础医学院,河北张家口075000 [2]河北医科大学附属石家庄市第五医院检验科,河北石家庄050023 [3]河北北方学院医学检验学院,河北张家口075000

出　　处：《中国医学创新》2024年第1期149-154,共6页Medical Innovation of China

基　　金：河北省自然科学基金(C2018405046);河北北方学院省属高校基本科研项目(JYT2020021);河北北方学院大学生创新创业训练计划项目(xj202151)。

摘　　要：泛素特异性蛋白酶(ubiquitin-specific proteases,USPs)家族是去泛素化酶家族中成员最多的一种,主要存在于骨骼肌、心脏、肝脏、脑、胰腺等组织中,且在不同物种间有表达差异性。目前的研究表明,虽然USPs特异性选择水解的泛素链的机制还不清楚,但USPs在机体生命过程中有极大作用,USPs在调控肿瘤发生及转移、免疫调节、炎症反应、能量代谢、病毒感染等方面具有重要临床意义。本文综述了近年来部分USPs生物学功能的研究进展,期望能够对相关疾病的诊断及治疗提供新的思路。The family of ubiquitin-specific proteases(USPs)is the most abundant member of the deubiquitinating enzyme family,different and is mainly present in skeletal muscle,heart,liver,brain,pancreas and other tissues,with differential expression among different species.Current studies have shown that the USPs has a great role in organismal life processes,although the mechanism by which the USPs specifically selects ubiquitin chains for hydrolysis is not clear.USPs have important clinical significances in the regulation of tumorigenesis and metastasis,immune regulation,inflammatory response,energy metabolism and viral infection.In this paper,we review reserch progress on biological functions of partial USPs in recent years,expecting to provide new ideas for the diagnosis and treatment of related diseases.

关 键 词：泛素特异性蛋白酶 肿瘤 治疗靶点 

分 类 号：R341[医药卫生—基础医学]