闪光放射治疗(Flash-RT)技术的研究进展  

Advance on research of Flash-RT technology

作　　者：戴相昆[1] 吴韶鹃 王金媛[1] 俞伟[1] 杜乐辉[1] 阎长鑫 张石磊 马娜[1] 雷霄 曲宝林[1] Dai Xiangkun;Wu Shaojuan;Wang Jinyuan;Yu Wei;Du Lehui;Yan Changxin;Zhang Shilei;Ma Na;Lei Xiao;Qu Baolin(Department of Radiotherapy,The First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心放射治疗科,北京100853

出　　处：《中国医学装备》2024年第1期2-8,共7页China Medical Equipment

基　　金：科研课题(ALB23J008)。

摘　　要：经过多年发展,精准放射治疗技术已广泛应用,但现有技术仍受限于正常组织耐受剂量的限制,无法实现肿瘤治疗的最佳目标。闪光放射治疗(Flash-RT)是一种以超高剂量率射束(UHDR)进行照射的放射治疗技术,能够在显著降低正常组织辐射损伤的同时,最大限度地治疗肿瘤。但直到目前,Flash-RT的生物学机制、关键物理参数及触发机制等尚不明确,其原理及临床转化应用仍处于研究阶段。本综述通过归纳Flash-RT相关研究,阐明Flash-RT研究的技术进展及临床转化应用。At present,precise radiotherapy has been widely used through the development with many years,but the existing technique still is limited by the limitation of tolerance dose of normal tissues,which cannot achieve the optimal goal of treating tumor.Flash radiotherapy(Flash-RT)is one kind of radiotherapy technique that uses the beam with ultrahigh dose rate(UHDR)to conduct irradiation,which can furthest treat tumors while significantly reduce radiation injury of normal tissues.But until now,the biological mechanism,key physical parameters and triggering mechanism of Flash-RT are still unclear,and its principle and clinical translational application are still in the stage of research.This review clarified the technological advance and clinical translational application of Flash-RT research through summarized the relevant research of Flash-RT.

关 键 词：放射治疗 超高剂量率 闪光放射治疗(Flash-RT) 

分 类 号：R815[医药卫生—放射医学]