闪光放射治疗对比常规放射治疗在放射性肺损伤中的机制探索  

Study on the mechanism of lung injury induced by ultra-high dose rate Flash radiation therapy versus traditional radiotherapy

作　　者：王瑶[1,2] 俞伟[1] 张沛 戴相昆[1] 刘畅[2] 曲宝林[1] Wang Yao;Yu Wei;Zhang Pei;Dai Xiangkun;Liu Chang;Qu Baolin(Department of Radiotherapy,The First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of General Medicine,Eastern Medical Branch of Chines PLA General Hospital,Beijing 101100,China)

机构地区：[1]解放军总医院第一医学中心放射治疗科,北京100853 [2]解放军总医院京东医疗区综合内科,北京101100

出　　处：《中国医学装备》2024年第1期15-20,共6页China Medical Equipment

摘　　要：放射治疗是治疗肺癌的重要手段,但容易造成肺部损伤并降低患者生活质量。闪光放射治疗(Flash-RT)因其极短的辐射时间和高剂量率备受关注,其在保证肿瘤治疗强度的同时,能够减少正常组织毒性反应。Flash-RT能否减少放射性肺损伤成为近年重点研究课题。本综述基于文献分析方法,通过检索国内外相关文献,系统评估Flash-RT与常规剂量率放射治疗对肺损伤的影响及其机制。通过综述Flash-RT与常规剂量率放射治疗对肺损伤的影响及其机制对比,为肺癌患者的治疗提供科学依据。Flash-RT与常规剂量率放射治疗相比,可以显著减少肺损伤并提高患者生活质量。未来仍需深入探索Flash-RT的机制,开发适用于不同肿瘤的Flash-RT装置和开展大规模临床研究。Radiotherapy is an important means to treat lung cancer,but it is easy to cause lung injury and reduce the quality of life of patients.Flash radiotherapy(FLASH-RT)has attracted attention due to its extremely short radiation duration and high dose rate,which can reduce toxicity of normal tissue while ensures treatment intensity of tumor.Whether Flash-RT can reduce radiation-induced lung injury has become an important research topic in recent years.Based on the literature analysis method,this review systematically assessed the effects and mechanisms of Flash-RT and radiotherapy with conventional dose rate on lung injury through searching relevant literatures at home and abroad,so as to provide scientific basis for the treatment of patients with lung cancer by reviewing the comparisons about the effects and mechanisms between Flash-RT and radiotherapy with conventional dose rate on lung injury.Compared with radiotherapy with conventional radiation rate,Flash-RT can significantly reduce lung injury and improve quality of life of patients.It is still demanded to explore the Flash-RT mechanism in future,so as to develop the Flash-RT instrument that is suitable for different tumors and to conduct larger-scale clinical researches.

关 键 词：超高剂量率 闪光放射治疗(Flash-RT) 常规剂量率放疗 肺损伤 放射治疗技术 

分 类 号：R818.74[医药卫生—放射医学]