四维超声联合母体血清学在胎儿颜面部畸形筛查中的价值研究  

Study on the application value of four-dimensional ultrasound combined with maternal serological screening in fetal facial deformities

作　　者：陈寸 王冰冰 林莉妃 陈垂婉 Chen Cun;Wang Bingbing;Lin Lifei;Chen Chuiwan(Ultrasound and Electrophysiology Department,Hainan Branch,Shanghai Children's Medical Center,School of Medicine,Shanghai JiaoTong University,Sanya 572000,China;Laboratory,Hainan Branch,Shanghai Children's Medical Center,School of Medicine,Shanghai JiaoTong University,Sanya 572000,China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心海南医院超声电生理科,三亚572000 [2]上海交通大学医学院附属上海儿童医学中心海南医院检验科,三亚572000

出　　处：《中国医学装备》2024年第1期93-96,共4页China Medical Equipment

基　　金：海南省卫生计生行业科研项目(20A210272)。

摘　　要：目的:探讨四维超声联合母体血清学在胎儿颜面部畸形筛查中的价值。方法:选取2020年1月至2022年12月在三亚市妇幼保健院(三亚市妇女儿童医院)做产检筛查的106例疑似胎儿颜面畸形孕中期孕妇,均行四维超声以及母体血清学检查,以分娩或者引产结果作为诊断的“金标准”,比较四维超声、母体血清学单项及联合检查对胎儿颜面部畸形的诊断价值。结果:受试者工作特征(ROC)曲线分析显示,四维超声、母体血清学和四维超声联合母体血清学诊断胎儿颜面畸形的ROC曲线下面积(AUC)分别为0.932、0.863和0.981。四维超声及母体血清学单独诊断胎儿颜面畸形的灵敏度及准确率显著低于二者联合诊断,差异均有统计学意义(x^(2)=11.173、0.064,P<0.05)。结论:四维超声联合母体血清学筛查可提高对胎儿颜面畸形的诊断准确率。Objective:To explore the application value of four-dimensional ultrasound combined with maternal serological screening in fetal facial deformities.Methods:A total of 106 pregnant women at mid pregnancy,whose fetuses with suspected fetal facial deformities and who conducted prenatal screening in Sanya Maternal and Child Health Hospital(Sanya Women and Children's Hospital)from January 2020 to December 2022,were selected.All of them underwent four-dimensional ultrasound and maternal serological screening.The results of delivery or induced labor were used as the gold standard of diagnosis to compare the diagnostic values of single four-dimensional ultrasound,single maternal serological screening and the combination of them for fetal facial deformities.Results:The analysis of the receiver operating characteristic(ROC)curve showed that the area under curve(AUC)values of four-dimensional ultrasound,maternal serological screening and the combination of them were respectively 0.932,0.863 and 0.981 in diagnosing fetal facial deformities.Both the sensitivities and accuracies of four-dimensional ultrasound and maternal serological screening were significantly lower than those of the combined diagnosis of them in diagnosing fetal facial deformities,and the differences of them were statistical significance(x^(2)=11.173,0.064,P<0.05),respectively.Conclusion:Four-dimensional ultrasound combines with maternal serological screening can improve the diagnostic accuracy for fetal facial deformities.

关 键 词：四维超声 母体血清学 胎儿颜面部畸形 

分 类 号：R445.1[医药卫生—影像医学与核医学]