三叶青总黄酮对热性惊厥所致炎症反应的抑制作用研究  

Research on the Inhibitory Effect of Total Flavonoids in Sanyeqing on Inflammatory Response Caused by Febrile Convulsions

作　　者：吉薇薇 Ji Weiwei(Zhejiang Pharmaceutical University,Ningbo,Zhejiang 315500)

机构地区：[1]浙江药科职业大学,浙江宁波315500

出　　处：《科技与健康》2023年第23期40-43,共4页Technology and Health

基　　金：浙江省基础公益研究计划项目(LGF20H280009);宁波市自然科学基金项目(2021J188)。

摘　　要：热性惊厥(febrile seizure,FS)是最常见的儿童惊厥疾病类型,重复发作的FS可能会导致脑损伤。然而,目前尚未发现预防或阻止重复FS的有效方法。研究了三叶青总黄酮(TFTH)对实验性重复FS大鼠的抑制作用。结果显示,TFTH显著延长了FS幼龄大鼠海马的惊厥潜伏期,并缩短了惊厥发作的持续时间,且可改善FS所致的海马神经元损伤。此外,TFTH还显著降低了FS造模后海马中白细胞介素-1β(IL-1β)的水平,并提高了抗炎细胞因子IL-1ra的水平,纠正了IL-1β和IL-1ra之间的失衡。同时,与模型组相比,TFTH治疗组大鼠海马中1型IL-1受体(IL-1R1)的表达明显降低。研究发现,TFTH可能能够抑制重复性FS诱导的炎症反应,这与调节IL-1β/IL-1ra信号传导的激活有关。Fever induced seizures(FS)are the most common type of seizures in children,and repeated episodes of FS may lead to brain damage.However,no effective methods have been found to prevent or prevent duplicate FS.The purpose of this study is to elucidate the inhibitory effect of total flavonoids from Sanyeqing(TFTH)on experimental repeated FS rats.The results showed that TFTH significantly prolonged the latent period of seizures in the hippocampus of FS young rats,shortened the duration of seizures,and improved hippocampal neuronal damage caused by FS.In addition,TFTH significantly reduced interleukin-1 in the hippocampus after FS modeling period of,the level of IL-1 was improved,and the level of anti-inflammatory cytokine IL-1ra was increased,correcting the imbalance between IL-1ra and IL-1β.Meanwhile,compared with the model group,the expression of type 1 IL-1 receptor(IL-1R1)in the hippocampus of rats treated with TFTH was significantly reduced.Research has found that TFTH may be able to inhibit repetitive FS induced infl ammatory response,which is related to regulating IL-1β/IL-1ra signaling.

关 键 词：热性惊厥 三叶青 IL-1Β IL-1RA 炎症反应 

分 类 号：R284.1[医药卫生—中药学]