自拟补肺益肾汤联合舒利迭治疗矽肺肺肾气虚证对肺纤维化进程、血气指标的影响  

Effects of Self-made Bufei Yishen Decoction(自拟补肺益肾汤)Combined with Seretide on Process of Pulmonary Fibrosis and Blood Gas Indexes of Silicosis with Qi Deficiency of Kidney and Lung Syndrome

作　　者：任淑燕 方庆娟 路志芳 曹秀丽 李新鹏 莘翼翔 张华 崔彩梅 REN Shuyan;FANG Qingjuan;LU Zhifang;CAO Xiuli;LI Xinpeng;XIN Yixiang;ZHANG Hua;CUI Caimei(Department of Respiratory Medicine,Zhangjiakou First Hospital,Zhangjiakou 075000,Hebei,China)

机构地区：[1]张家口市第一医院呼吸科,河北张家口075000

出　　处：《辽宁中医杂志》2023年第11期84-87,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探讨自拟补肺益肾汤联合舒利迭治疗矽肺肺肾气虚证对肺纤维化进程、血气指标的影响。方法回顾性选取2018年1月—2019年12月在该院治疗的矽肺患者120例,按照随机数字表法分为对照组60例和观察组60例。对照组给予西医常规治疗,观察组加用自拟补肺益肾汤治疗。比较症状评分;检测血气指标、肺纤维化指标、肺功能相关指标的水平;观察安全性。结果治疗后,观察组和对照组的咳嗽、咯痰、喘息、气短、易感等评分较治疗前下降,且观察组症状评分较对照组低(P<0.05);治疗后,观察组和对照组的动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))较治疗前上升,动脉血二氧化碳分压(PaCO_(2))较治疗前下降,且观察组血气指标较对照组改善更明显(P<0.05);治疗后,观察组和对照组的Ⅲ型前胶原肽(PⅢP)、Ⅳ型胶原(CⅣ)、Ⅰ型前胶原羧基末端前肽(PⅠCP)较治疗前下降,且观察组肺纤维化指标较对照组低(P<0.05);治疗后,观察组的第1秒用力呼气容积(FEV1)、用力呼气量(FVC)、FEV1/FVC及6分钟步行距离(6MWT)较治疗前上升,对照组上述指标与治疗前比较,未见明显差异,且观察组上述指标改善较对照组明显(P<0.05)。结论自拟补肺益肾汤联合西医常规治疗矽肺肺肾气虚证可减轻咳嗽、咯痰、喘息、气短、易感等症状,在改善血气、肺功能及肺纤维化方面影响积极。Objective To explore the effect of Self-made Bufei Yishen Decoction(自拟补肺益肾汤)combined with seretide on the process of pulmonary fibrosis and blood gas indexes in the treatment of Qi deficiency of kidney and lung syndrome of silicosis.Methods A total of 120 silicosis patients treated in the hospital from January 2018 to December 2019 were retrospectively se-lected and randomly divided into 60 cases in the control group and 60 cases in the observation group.The control group was trea-ted with routine western medicine,and the observation group was treated with self-made Bufei Yishen Decoction.The symptom scores were compared and the levels of blood gas,pulmonary fibrosis and pulmonary function were measured.The safety was ob-served.Results After treatment,the scores of cough,expectoration,wheezing,shortness of breath and susceptibility in the observa-tion group and the control group decreased compared with those before treatment,and the symptom scores in the observation group were lower than those in the control group(P<0.05).After treatment,the arterial oxygen partial pressure(PaO_(2))and blood oxy-gen saturation(SaO_(2))in the observation group and the control group increased,the arterial carbon dioxide partial pressure(PaCO_(2))decreased,and the blood gas indexes in the observation group improved more significantly than those in the control group(P<0.05).After treatment,the levels of typeⅢprocollagen peptide(PⅢP),typeⅣcollagen(CⅣ)and typeⅠprocolla-gen carboxy terminal procollagen(PⅠCP)in the observation group and the control group decreased compared with those before treatment,and the indexes of pulmonary fibrosis in the observation group were lower than those in the control group(P<0.05).After treatment,the first second forced expiratory volume(FEV1),forced expiratory volume(FVC),FEV1/FVC and 6-minute walking distance(6MWT)in the observation group increased compared with those before treatment.There was no significant difference between the above indexes in the control group and those be

关 键 词：补肺益肾汤 矽肺 肺肾气虚证 血气 肺纤维化 

分 类 号：R256.1[医药卫生—中医内科学]