参苓白术散加减治疗非小细胞肺癌肺脾两虚型癌因性疲乏的临床疗效及对免疫功能的影响  

Clinical Efficacy of Modified Shenling Baizhu Powder(参苓白术散加减)in Treatment of Cancer-Related Fatigue in Non-Small Cell Lung Cancer of Lung-Spleen Deficiency Type and Its Influence on Immune Function

作　　者：周岩[1] 田乃菊 赵玮璿 汤雨 张法英[1] 李莹 ZHOU Yan;TIAN Naiju;ZHAO Weixuan;TANG Yu;ZHANG Faying;LI Ying(Oncology Department of Traditional Chinese Medicine,Beijing Chaoyang District Hospital of Traditional Chinese Medicine,Beijing 100020,China)

机构地区：[1]北京市朝阳区中医医院中医肿瘤科,北京100020

出　　处：《辽宁中医杂志》2023年第11期124-128,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：北京市中医药传承“双百工程”项目;北京市朝阳区科技计划项目(CYSF1723)。

摘　　要：目的分析参苓白术散加减治疗非小细胞肺癌肺脾两虚型癌因性疲乏的临床疗效及对免疫功能的影响。方法选取102例非小细胞肺癌肺脾两虚型癌因性疲乏患者,随机分为试验组和对照组各51例。对照组接受基础治疗,试验组在对照组的基础上接受参苓白术散加减治疗。比较两组治疗4周后的临床疗效;比较两组治疗前及治疗4周后的中医证候积分、癌因性疲乏评分(Piper疲乏量表)、血清T细胞亚群(CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+))水平及生活质量[生活质量评分(EORTC QLQ-C30)]。结果试验组治疗4周后的治疗总有效率为88.24%(45/51),对照组的治疗总有效率为70.00%(35/50),组间比较差异有统计学意义(P<0.05);两组治疗后的腹胀纳呆、痰白清稀、神疲乏力、气短而喘中医证候积分较治疗前均明显降低,且试验组显著低于对照组(P<0.05);两组治疗后的Piper疲乏量表总分及平均分较治疗前明显降低,且试验组显著低于对照组(P<0.05);两组治疗后的血清CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平较治疗前明显升高,CD_(8)^(+)水平较治疗前明显降低,组间比较差异有统计学意义(P<0.05);试验组治疗后的EORTC QLQ-C30量表5个功能维度中躯体功能、角色功能、情绪功能、认知功能、社会功能评分显著高于对照组,差异有统计学意义(P<0.05)。结论参苓白术散加减治疗可有效改善非小细胞肺癌肺脾两虚型患者的癌因性疲乏状况及免疫功能,缓解中医证候,保障其生活质量。Objective To analyze the clinical efficacy of Modified Shenling Baizhu Powder(参苓白术散加减)in the treat-ment of cancer-related fatigue in non-small cell lung cancer of lung-spleen deficiency type and its influence on immune func-tion.Methods A total of 102 patients with non-small cell lung cancer of lung-spleen deficiency type complicated with cancer-related fatigue were selected and randomly divided into the experimental group and the control group,with 51 cases in each group.The control group received basic treatment,while the experimental group was given Modified Shenling Baizhu Powder on the basis of the control group.The clinical efficacy after 4 weeks of treatment as well as TCM syndromes scores,cancer-related fatigue score(Piper fatigue scale),serum T cell subsets(CD_(3)^(+),CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+))and quality of life[EORTC Quality of Life Ques-tionnaire Core 30(EORTC QLQ-C30)]before treatment and after 4 weeks of treatment were compared between the two groups.Results After 4 weeks of treatment,the total effective rate of treatment was 88.24%(45/51)in the experimental group and that in the control group was 70.00%(35/50)(P<0.05).The scores of TCM syndromes such as abdominal distension and anorexia,white and thin phlegm,fatigue and shortness of breath and asthma were significantly reduced in the two groups compared with those before treatment,and the scores in the experimental group were significantly lower than those in the control group(P<0.05).The total score and average score of Piper fatigue scale in both groups after treatment were significantly lower than those before treatment,and the scores were significantly lower in the experimental group than those in the control group(P<0.05).The levels of serum CD_(3)^(+),CD_(4)^(+)and CD_(4)^(+)/CD_(8)^(+)in the two groups after treatment were significantly enhanced while the level of CD_(8)^(+)was significantly declined compared to those before treatment,and the differences between the groups were statistically significant(P<0.05

关 键 词：参苓白术散 非小细胞肺癌 肺脾两虚型 癌因性疲乏 免疫功能 

分 类 号：R256.1[医药卫生—中医内科学]