复方丹参滴丸联合尼可地尔对非阻塞性冠脉缺血性疾病的影响  

Effect of Compound Danshen Dropping Pills(复方丹参滴丸)Combined with Nicorandil on Left Ventricular Diastolic Function in Patients with INOCA

作　　者：郭艳娇 张克成[1] 王丽杰 韩培天[1] 王文州[1] 王田林 李文慧[1] GUO Yanjiao;ZHANG Kecheng;WANG Lijie;HAN Peitian;WANG Wenzhou;WANG Tianlin;LI Wenhui(Department of Cardiology,The Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,Hebei,China)

机构地区：[1]河北北方学院附属第二医院心内科,河北张家口075100

出　　处：《辽宁中医杂志》2023年第12期61-64,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：张家口市科技局计划项目(2121179D)。

摘　　要：目的观察复方丹参滴丸联合尼可地尔对非阻塞性冠脉缺血性疾病(ischemia with non-obstructive coronary artery disease,INOCA)患者左室舒张功能的影响,为临床用药提供参考。方法选取2020年1月—2022年1月医院收治的112例INOCA患者为研究对象,根据随机原则分为对照组56例(给予常规方案+尼可地尔)和观察组56例(给予常规方案+尼可地尔+复方丹参滴丸)。比较用药前后两组INOCA患者心功能指标、微循环指标及氨基末端前体脑钠肽原(amino-terminal pro-brain natriuretic peptide,NT-proBNP)、超敏-C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平的差异,并统计用药期间不良反应率和3个月内不良心脏事件发生率。结果治疗前,两组INOCA患者心功能指标比较,差异无统计学意义(P>0.05);治疗后发现两组INOCA患者左心室射血分数(left ventricular ejectior fraction,LVEF)、左室舒张早期快速充盈峰E峰/左室舒张晚期充盈A峰(E/A)较前升高,而室间隔舒张末期厚度(interventriallar septal end diastdic thickness,IVSD)、左室后壁舒张末期厚度(left ventricular posterior wall end diastolic thickness,LVPWD)、二尖瓣E峰流速/二尖瓣环e′速度(E/E’)则较前下降,且组间比较提示观察组上述心功能指标均优于对照组,差异有统计学意义(P<0.05)。治疗前,两组INOCA患者微循环指标、血清因子比较,差异无统计学意义(P>0.05);治疗后发现两组INOCA患者心肌平台期强度、再充盈平均速度及冠状动脉血流储备功能(coronary flow reserve function,CFR)较前升高,而NT-proBNP、hs-CRP则较前下降,且组间比较提示观察组上述微循环指标、血清因子均优于对照组,差异有统计学意义(P<0.05)。两组INOCA患者用药期间不良反应率、3个月内不良心脏事件发生率比较,差异无统计学意义(P>0.05)。结论复方丹参滴丸联合尼可地尔治疗INOCA可改善患者左室舒张功能和冠状动脉血流储备功能,降低相�Objective To observe the effect of Compound Danshen Dropping Pills(复方丹参滴丸)combined with nicorandil on left ventricular diastolic function in patients with ischemia with non-obstructive coronary artery disease(INOCA)to provide reference for clinical medication.Methods A total of 112 patients with INOCA who were admitted to the hospital from January 2020 to January 2022 were selected as the research objects,and they were randomly divided into the control group(56 cases,given the routine regimen+nicorandil)and the observation group(56 cases,the routine scheme+nicorandil+Compound Danshen Dropping Pills).The cardiac function indexes,microcirculation indexes,amino-terminal pro-brain natriuretic peptide(NT-proBNP)and high-sensitivity-C-reactive protein(hs-CRP)were comapred between the two groups before and after treatment.The differences in levels were calculated,and the adverse reaction rate during medication and the incidence of adverse cardiac events within 3 months were calculated.Results Before treatment,there was no statistically significant difference in cardiac function indicators between the two groups(P>0.05).After treatment,it was found that the left ventricular ejection fraction(LVEF),early diastolic fast filling peak E/late diastolic filling peak A(E/A)of the two groups increased,while the interventricular septal end diastolic thickness(IVSD),left ventricular posterior wall end diastolic thickness(LVPWD)and mitral E peak flow velocity/mitral annular e′velocit(E/E′)decreased and the inter group comparison showed that the observation group had better cardiac function indicators than the control group.The difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in microcirculation indicators or serum factors between the two groups(P>0.05).After treatment,it was found that the myocardial plateau intensity,mean velocity of reperfusion and coronary flow reserve function(CFR)of two groups increased while NT proBNP and hs-CRP decreased.The c

关 键 词：复方丹参滴丸 尼可地尔 非阻塞性冠脉缺血性疾病 左室舒张功能 

分 类 号：R256.2[医药卫生—中医内科学]