非酒精性脂肪肝患者血清HA、PC-Ⅲ、Ⅳ-C水平变化及其与中医证型的关系  

Changes of Serum HA,PC-ⅢandⅣ-C in Patients with NAFLD and Their Relationship with TCM Syndrome Types

作　　者：徐艺真 杜时雨[2] 葛成慧 XU Yizhen;DU Shiyu;GE Chenghui(Second Affiliated Hospital of Xingtai Medical College,Xingtai 054000,Hebei,China;Beijing China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]邢台医学高等专科学校第二附属医院,河北邢台054000 [2]北京市中日友好医院,北京100029

出　　处：《辽宁中医杂志》2023年第12期74-76,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：北京市自然科学基金项目(7202181)。

摘　　要：目的探究非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)患者血清透明质酸(hyaluronic acid,HA)、Ⅲ型前胶原(typeⅢprocollagen,PC-Ⅲ)、Ⅳ型胶原(typeⅣcollagen,Ⅳ-C)水平变化及其与中医证型的关系。方法选取2018年10月—2019年2月医院收治的66例NAFLD患者为研究对象,依照病情严重程度将患者分为轻度组(25例)、中度组(21例)、重度组(20例),并选择同期正常健康体检者35例作为对照组,检测全部受试对象血清HA、PC-Ⅲ、Ⅳ-C水平,并进行中医辨证分型,比较各组血清HA、PC-Ⅲ、Ⅳ-C水平,并分析上述血清指标与中医证型的关系。结果各组血清HA、PC-Ⅲ、Ⅳ-C水平比较差异具有统计学意义(P<0.05),且轻度组、中度组、重度组均高于对照组,中度组、重度组均高于轻度组,重度组高于中度组(P<0.05);根据中医诊断标准,辨证为痰浊内阻证14例(21.21%);湿热蕴结证17例(25.76%);脾肾两虚证18例(27.27%);痰瘀互结证17例(25.76%);中医不同证型NAFLD患者血清HA、PC-Ⅲ、Ⅳ-C水平比较,差异有统计学意义(P<0.05);痰瘀互结证患者上述血清指标高于其他证型(P<0.05)。结论血清HA、PC-Ⅲ、Ⅳ-C水平能反映NAFLD病情严重程度,且对患者的中医辨证分型具有一定的临床指导意义。Objective To explore the levels of serum hyaluronic acid(HA),typeⅢprocollagen(PCⅢ)and type IV collagen(IV-C)in patients with non-alcoholic fatty liver disease(NAFLD),and their relationship with TCM syndrome types.Methods A total of 66 patients with NAFLD admitted to the hospital from October 2018 to February 2019 were selected,and divided into mild group(25 cases),moderate group(21 cases)and severe group(20 cases)according to the severity.35 healthy individuals were selected as the control group.The levels of serum HA,PC-Ⅲand IV-C in all groups were detected,and TCM syndrome differentiation was performed.The levels of serum HA,PC-ⅢandⅣ-C were compared among the groups,and the relationship between the above-mentioned serum indexes and TCM syndrome types was analyzed.Results The levels of serum HA,PCⅢand IV-C in each group showed statistically significant differences(P<0.05),and the levels of the mild,moderate and severe groups were all higher than those of the control group.The levels of the moderate and severe groups were all higher than those of the mild group,and the levels of the severe group were higher than those of the moderate group(P<0.05).According to the diagnostic criteria of traditional Chinese medicine,14 cases(21.21%)were diagnosed as phlegm turbidity internal obstruction syndrome,17 cases(25.76%)of dampness-heat accumulation syndrome,18 cases(27.27%)of spleen and kidney deficiency syndrome,17 cases(25.76%)of phlegm and blood stasis syndrome.There was a statistically significant difference in the levels of serum HA,PC-Ⅲand IV-C among NAFLD patients with different syndrome types in traditional Chinese medicine(P<0.05).The above serum indicators in patients with phlegm and blood stasis syndrome were higher than those in other syndrome types(P<0.05).Conclusion The levels of serum HA,PC-ⅢandⅣ-C can reflect the severity of NAFLD and are helpful for TCM syndrome differentiation.

关 键 词：非酒精性脂肪肝 透明质酸 Ⅲ型前胶原 Ⅳ型胶原 中医证型 

分 类 号：R256.4[医药卫生—中医内科学]