参附注射液对全髋关节置换术患者围术期循环稳定性及下肢深静脉血栓形成的影响  

Effects of Shenfu Injection(参附注射液)on Perioperative Circulation Stability and Deep Venous Thrombosis of Lower Extremity in Patients Undergoing Total Hip Arthroplasty

作　　者：涂学云[1] 万仑[1] 王丹丹[1] 李有武[1] TU Xueyun;WAN Lun;WANG Dandan;LI Youwu(Guangdong Second Hospital of Traditional Chinese Medicine,Guangzhou 510000,Guangdong,China)

机构地区：[1]广东省第二中医院,广东广州510000

出　　处：《辽宁中医杂志》2023年第12期91-94,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目立项项目(20212015)。

摘　　要：目的观察参附注射液对全髋关节置换术患者围术期循环稳定性及下肢深静脉血栓形成的影响。方法研究纳入63例全髋关节置换术患者(2020年2月—2022年2月收治),将纳入患者以随机数字表法分为对照组31例与观察组32例,对照组患者常规治疗(等量生理盐水),观察组患者于术前及术后7 d给予患者参附注射液治疗。数据比较:两组患者围术期循环稳定性优良率、术前及术后7 d患者活化部分凝血活酶时间(activated partial thromboplastin time,APTT)及凝血酶原时间(prothrombin time,PT)、D-二聚体(D-dimer,D-D)等凝血功能指标变化、术后下肢深静脉血栓发生率、术中出血量、术后引流量及总输血量、下床活动时间及住院时间、不良反应发生率及术后6个月患者髋关节功能情况。结果观察组患者围术期循环稳定性优良率(96.88%,31/32)高于对照组患者(77.42%,24/31)(P<0.05);术前,两组患者APTT、PT及D-D等凝血功能指标比较(P>0.05),术后7 d两组患者APTT、PT指标均提升,D-D指标下降,观察组患者术后7 d APTT、PT指标高于对照组,D-D指标低于对照组患者(P<0.05);观察组患者术后下肢深静脉血栓发生率(0.00%,0/32)低于对照组患者(12.90%,4/31)(P<0.05);观察组患者术中出血量、术后引流量及总输血量均少于对照组,下床活动时间及住院时间短于对照组(P<0.05);观察组患者不良反应发生率(0.00%,0/32)低于对照组患者(12.90%,4/31)(P<0.05);观察组患者术后6个月髋关节功能恢复情况(93.75%,30/32)优于对照组患者(74.19%,23/31)(P<0.05)。结论参附注射液可较好改善全髋关节置换术患者围术期循环稳定性,可较好预防术后下肢深静脉血栓形成,还可促进患者更快康复,安全可靠,患者术后6个月髋关节功能恢复更好,值得应用。Objective To observe the effects of Shenfu Injection(参附注射液)on perioperative circulation stability and deep venous thrombosis of lower extremity in patients undergoing total hip arthroplasty.Methods The study included 91 patients with total hip replacement(February 2020 to February 2022)and the patients were divided into control group(45 cases)and observation group(46 cases)by random number table method.The patients of the control group were treated with conventional treatment(amount of saline).Those of the observation group were treated with Shenfu Injection before and 7 d after operation.The excellent rate of perioperative circulatory stability in both groups of patients,changes in coagulation function indicators such as activated partial thromboplastin time(APTT),prothrombin time(PT),D-dimer(D-D),postoperative incidence of lower limb deep vein thrombosis,intraoperative bleeding volume,postoperative drainage volume and total transfusion volume,time of ambulation and hospitalization time as well as changes in APTT,PT and D-D before and 7 days after operation.The incidence of adverse reactions and the hip joint function of patients at 6 months after surgery.Results The excellent and good rate of perioperative circulation stability in the observation group(96.88%,31/32)was higher than that in the control group(77.42%,24/31)(P<0.05).The preoperative comparison of coagulation function indexes,such as APTT,PT and D-D,between the two groups had no significance(P>0.05).7 days after surgery,the levels of APTT and PT in each group were improved,while D-D value was decreased.7 days after surgery,the levels of APTT and PT in the observation group were higher than those of the control group,while D-D value was lower than that of the control group(P<0.05).The incidence of postoperative deep vein thrombosis of lower limbs in the observation group(0.00%,0/32)was lower than that in the control group(12.90%,4/31)(P<0.05).The amount of intraoperative blood loss,postoperative drainage and total blood transfusion in the ob

关 键 词：全髋关节置换术 参附注射液 生理盐水 围术期循环稳定性 下肢深静脉血栓 髋关节功能 

分 类 号：R274[医药卫生—中医骨伤科学]