自拟愈合汤对肛周脓肿根治术后患者CD_(4)^(+)、CD_(8)^(+)水平的影响  

Changes of CD_(4)^(+)and CD_(8)^(+)in Patients with Perianal Abscess after Radical Resection with Self-Designed Healing Decoction(自拟愈合汤)

作　　者：房栩丞 杨影 杨淑雯 郑萍 王婴 焦翔 FANG Xucheng;YANG Ying;YANG Shuwen;ZHENG Ping;WANG Ying;JIAO Xiang(Changji Hui Autonomous Prefecture Hospital of Traditional Chinese Medicine,Changji 831100,Xinjiang,China)

机构地区：[1]新疆维吾尔自治区昌吉回族自治州中医医院,新疆昌吉831100

出　　处：《辽宁中医杂志》2023年第12期98-101,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：新疆维吾尔自治区自然科学基金项目(2021D01A10)。

摘　　要：目的观察自拟愈合汤对肛周脓肿根治术后患者CD_(4)^(+)、CD_(8)^(+)水平的影响。方法研究纳入160例肛周脓肿根治术患者(2020年2月—2022年5月收治)进行该次试验研究,以随机数字表法将患者分为对照组与治疗组,各80例。对照组患者术后常规每日换药处理,治疗组患者行每日换药+自拟愈合汤治疗。治疗后患者临床疗效及创面愈合率、创面完全愈合时间、创面恢复评分、术后7 d及术后14 d各组患者创面大小变化、手术后7 d及术后14 d免疫功能指标变化、肛门功能评分(Wexner评分)、生活质量评分(SF-36量表评分)变化。结果治疗组治疗总有效率比对照组更高[96.25%(77/80)vs 87.50%(70/80)](P<0.05);治疗组患者创面愈合率比对照组高(58.17%vs 44.74%),且治疗组患者创面完全愈合时间比对照组更短(P<0.05);术后7 d两组创面面积相比(P>0.05),术后14 d治疗组患者创面面积小于对照组(P<0.05);术后14 d两组患者创面疼痛差异无统计学意义,创面水肿差异无统计学意义(P>0.05),而创面渗液及创面肉芽对比(P<0.05);术前各组患者CD_(4)^(+)、CD_(8)^(+)指标均偏低,术后7 d各组治疗组患者CD_(4)^(+)、CD_(8)^(+)指标均一定程度上升,但组间比较差异无统计学意义(P>0.05);术后14 d各组患者CD_(4)^(+)、CD_(8)^(+)指标均上升,治疗组高于对照组(P<0.05);治疗后各组患者Wexner评分、SF-36量表评分均改善,而治疗组患者治疗后Wexner评分、SF-36量表评分均优于对照组(P<0.05)。结论自拟愈合汤可提升肛周脓肿根治术患者治疗效果,患者创面恢复好、恢复快,且肛门功能及免疫功能、生活质量均改善,值得应用。Objective To observe the effect of Self-Designed Healing Decoction(自拟愈合汤)on the levels of CD_(4)^(+)and CD_(8)^(+)in patients with perianal abscess after radical operation.Methods A total of 160 patients undergoing radical perianal abscess surgery(February 2020 to May 2022)were included in this study.The patients were divided into control group and treatment group by random number table method,with 80 cases in each group.The patients in the control group were routinely treated with daily dressing change after surgery,while those in the treatment group were treated with daily dressing change and Self-Designed Healing Decoction.After treatment,the clinical efficacy,the wound healing rate,the wound complete healing time,the wound recovery score,the changes in wound size,the immune function index,the anal function score(Wexner score)and the quality of life score(SF-36 scale score)in each group at 7 and 14 days after surgery were observed.Results The total effective rate in the treatment group was higher than that in the control group[96.25%(77/80)vs 87.50%(70/80)](P<0.05).The wound healing rate in the treatment group was higher than that in the control group(58.17%vs 44.74%),and the time of complete wound healing in the treatment group was shorter than that in the control group(P<0.05).On postoperative day 7,the wound area of the two groups was not significant(P>0.05),and on postoperative day 14,the wound area of the treatment group was smaller than that in the control group(P<0.05).14 d after surgery,there was no difference in wound pain and wound edema between two groups(P>0.05),while the comparison of wound exudation and wound granulation had significance(P<0.05).The levels of CD_(4)^(+)and CD_(8)^(+)in each group were low before surgery,and the levels of CD_(4)^(+)and CD_(8)^(+)in each group were increased to some extent on the 7th day after surgery,but there was no difference between two groups(P>0.05).The levels of CD_(4)^(+)and CD8+in each group increased 14 days after operation,and the levels of the

关 键 词：肛周脓肿 自拟愈合汤 肛周脓肿根治术 免疫功能 创面 生活质量 

分 类 号：R266[医药卫生—中医外科学]