气阴两虚兼瘀阻经络证糖尿病高危足患者经复荣通脉胶囊辅助治疗的疗效及机制  

Efficacy and Mechanism of Adjuvant Therapy with Furong Tongmai Capsule(复荣通脉胶囊)in High-Risk Diabetic Foot Patients with Deficiency of Both Qi and Yin Combined with Blood Stasis in Meridians and Collaterals

作　　者：王猛[1] 高娟娟 姚彬 王丛香 苏秀海[1] 于文霞[1] WANG Meng;GAO Juanjuan;YAO Bin;WANG Congxiang;SU Xiuhai;YU Wenxia(Department of Endocrinology,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine·Hebei,Cangzhou 061000,Hebei,China)

机构地区：[1]河北省沧州中西医结合医院内分泌科,河北沧州061000

出　　处：《辽宁中医杂志》2023年第12期124-128,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局中医药类科研计划课题项目(2021301)。

摘　　要：目的研究气阴两虚兼瘀阻经络证糖尿病高危足患者经复荣通脉胶囊辅助治疗对其血液流变学及神经功能的影响。方法180例研究对象均选自河北省沧州中西医结合医院内分泌科2020年1月—2021年11月收治的糖尿病高危足患者,根据治疗方法的不同分为对照组(60例)以及观察组(120例)。两组均接受常规治疗,对照组在此基础上予以胰激肽原酶肠溶片,观察组在对照组基础上加用复荣通脉胶囊,两组均持续治疗24周。比较两组治疗后临床疗效,治疗前后踝肱指数(ankle brachial index,ABI)、足底峰值压力、中医症状评分,多伦多神经病变(Toronto clinical scoring system,TCSS)评分,血液流变学指标,神经传导速度以及治疗期间不良反应。结果治疗后,观察组临床总有效率高于对照组;与治疗前比,治疗后两组足底峰值压力、中医症状评分、TCSS各项评分及全血低切黏度、全血高切黏度、血浆黏度值、纤维蛋白原水平均降低,其中观察组低于对照组;ABI、腓总神经、胫神经、腓浅神经传导速度均升高,其中观察组高于对照组,差异有统计学意义(均P<0.05)。结论气阴两虚兼瘀阻经络证糖尿病高危足患者以复荣通脉胶囊辅助治疗能够有效降低足底峰值压力,改善血液流变学,提高神经传导速度,降低坏疽风险,疗效更佳。Objective To study the effect of adjuvant therapy with Furong Tongmai Capsule(复荣通脉胶囊)on blood rheology and neurological function in high-risk diabetic foot patients with deficiency of both Qi and Yin combined with blood stasis in meridians and collaterals.Methods A total of 180 subjects were selected from patients with high-risk diabetic foot who were admitted to the Department of Endocrinology,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine.Hebei from January 2020 to November 2021.According to different treatment methods,they were divided into control group(60 cases)and observation group(120 cases).Both groups received conventional treatment.The control group was additionally given pancreatic kininogenase enteric-coated tablets and the observation group was additionally given Furong Tongmai Capsule on the basis of the control group.Both groups received treatment for 24 weeks.The clinical efficacy after treatment,ankle brachial index(ABI),peak plantar pressure,TCM symptom score,Toronto clinical scoring system(TCSS)score,hemorheological indexes,nerve conduction velocity before and after treatment and adverse reactions during treatment were compared between the two groups.Results After treatment,the total clinical effective rate in the observation group was higher than that in the control group.Compared with those before treatment,the peak plantar pressure,TCM symptom score,TCSS scores,whole blood low-shear viscosity,whole blood high-shear viscosity,plasma viscosity value and fibrinogen level in the two groups decreased after treatment,and those of the observation group were lower than those of the control group.The conduction velocity of ABI,common peroneal nerve,tibial nerve and superficial peroneal nerve all increased,and those of the observation group were higher than those of the control group,and the differences were statistically significant(all P<0.05).Conclusion The adjuvant therapy of Furong Tongmai Capsule can effectively reduce the peak plantar pressure,improve blood

关 键 词：糖尿病高危足 气阴两虚兼瘀阻经络证 复荣通脉胶囊 足底峰值压力 血液流变学 神经传导速度 

分 类 号：R255.6[医药卫生—中医内科学]