芩连平胃汤加味对糜烂型口腔扁平苔藓脾胃湿热证的疗效及血清P物质和趋化素水平的影响  

Clinical Research of Qinlian Pingwei Decoction(芩连平胃汤)in Treatment of Erosive Oral Lichen Planus with Syndrome of Damp-Heat in Spleen and Stomach

作　　者：潘晓勤 张忠晶 张继生[3] 刘超[4] PAN Xiaoqin;ZHANG Zhongjing;ZHANG Jisheng;LIU Chao(Lishui District Stomatological Hospital,Nanjing 211200,Jiangsu,China;Nanjing Lishui People′s Hospital,Nanjing 211200,Jiangsu,China;Jiangsu Provincial People′s Hospital,Nanjing 210029,Jiangsu,China;Nanjing Stomatological Hospital,Nanjing 210018,Jiangsu,China)

机构地区：[1]南京市溧水区口腔病防治院,江苏南京211200 [2]南京市溧水区人民医院,江苏南京211200 [3]江苏省人民医院,江苏南京210029 [4]南京市口腔医院,江苏南京210018

出　　处：《辽宁中医杂志》2023年第12期139-142,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：江苏省基础研究计划(自然科学基金)项目(BK20161114)。

摘　　要：目的探讨芩连平胃汤加味治疗糜烂型口腔扁平苔藓(oral lichen planus,OLP)脾胃湿热证的疗效以及对血清P物质和趋化素水平的影响。方法筛选符合条件的糜烂型OLP脾胃湿热证病例共计76例,均来源于医院2018年1月—2021年12月接诊的患者,根据随机数字表法分为治疗组与对照组,每组38例。对照组患者进行常规治疗方案;治疗组于对照组基础上采取芩连平胃汤加味治疗。两组连续治疗4周。比较两组症状体征评分、脾胃湿热证单项症状评分、临床疗效以及血清P物质和趋化素水平。结果治疗4周后,两组症状与体征计分明显减少(P<0.01);治疗4周后,治疗组的症状与体征计分明显低于对照组(P<0.01);治疗4周后,两组脾胃湿热证单项症状评分明显减少(P<0.01);治疗4周后,治疗组的脾胃湿热证单项症状评分明显低于对照组(P<0.01);治疗4周后,治疗组的总有效率为97.37%(37/38),显著高于对照组的78.95%(30/38)(P<0.05);治疗4周后,两组血清P物质和趋化素水平明显下降(P<0.01);治疗4周后,治疗组血清P物质和趋化素水平明显低于对照组(P<0.01)。结论于常规措施的基础上,芩连平胃汤加味治疗糜烂型OLP脾胃湿热证的疗效更优,有利于患者症状、体征及中医证候的改善,以及抑制血清P物质和趋化素水平。Objective To investigate the efficacy of Qinlian Pingwei Decoction(芩连平胃汤)in the treatment of erosive oral lichen planus(OLP)with syndrome of damp-heat in spleen and stomach and its effect on serum levels of substance P and chemokine.Methods A total of 76 eligible erosive OLP cases with syndrome of damp-heat in spleen and stomach admitted to the hospital from January of 2018 to December of 2021 were screened and divided into the treatment group and the control group,with 38 cases in each group according to the random number table method.The control group received the routine treatment.The treatment group was treated with Qinlian Pingwei Decoction on the basis of the control group.The two groups were treated for 4 weeks.The symptom and sign scores,individual symptom scores of syndrome of damp-heat in spleen and stomach,the clinical efficacy and serum levels of substance P and chemokine were compared between the two groups.Results After 4 weeks of treatment,the scores of symptoms and signs of the two groups were significantly reduced(P<0.01).After 4 weeks of treatment,the scores of symptoms and signs in the treatment group were significantly lower than those in the control group(P<0.01).After 4 weeks of treatment,the scores of individual symptoms of syndrome of damp-heat in spleen and stomach were significantly reduced in the two groups(P<0.01).After 4 weeks of treatment,the single symptom score of syndrome of damp-heat in spleen and stomach in the treatment group was significantly lower than that in the control group(P<0.01).After 4 weeks of treatment,the total effective rate of the treatment group was 97.37%(37/38),which was significantly higher than that of the control group[78.95%(30/38),P<0.05].After 4 weeks of treatment,the serum levels of substance P and chemokine in the two groups were significantly decreased(P<0.01).After 4 weeks of treatment,the levels of serum substance P and chemokine in the treatment group were significantly lower than those in the control group(P<0.01).Conclusion On the basis

关 键 词：口腔扁平苔藓 芩连平胃汤 脾胃湿热证 P物质 趋化素 

分 类 号：R276.8[医药卫生—中医五官科学]