加味调神解郁汤治疗首发轻中度抑郁症临床疗效  

Clinical efficacy of Modified Tiaoshen Jieyu Decoction(加味调神解郁汤)in Treatment of First Mild to Moderate Depression

作　　者：姚雪强 沈仲夏[2] 倪忠根 YAO Xueqiang;SHEN Zhongxia;NI Zhonggen(Deqing people′s Hospital,Deqing 317000,Zhejiang,China;Huzhou Third People′s Hospital,Huzhou 313000,Zhejiang,China)

机构地区：[1]德清县人民医院,浙江德清317000 [2]湖州市第三人民医院,浙江湖州313000

出　　处：《辽宁中医杂志》2023年第12期143-146,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的研究加味调神解郁汤治疗首发轻中度抑郁症的临床疗效。方法选择2018年6月—2021年6月医院68例首发轻中度抑郁患者进行该次研究,按照简单抽签法分为研究组和对照组,两组均34例,对照组采用盐酸帕罗西汀片治疗,研究组采用加味调神解郁汤联合盐酸帕罗西汀片治疗。两组治疗疗程均为1个月。比较两组临床疗效,临床症状积分和汉密顿抑郁量表(Hamilton Depression Scale,HAMD)评分,生存质量测定量评分(quality of life,QOL)和匹茨堡睡眠质量指数量评分(Pittsburgh sleep quality index scale,PSQI),不良反应发生率。结果治疗后,研究组的总有效率为91.18%(31/34),显著高于对照组的64.71%(22/34)(P<0.05);两组治疗前临床症状积分、HAMD评分、PSQI评分差异均无统计学意义(P>0.05);治疗后,研究组临床症状积分、HAMD评分、PSQI评分分别为[(6.37±1.32)分,(8.17±2.65)分,(4.76±1.29)分],均显著低于对照组[(11.63±2.29)分,(12.78±2.97)分,(5.82±1.60)分](P<0.05);研究组QOL评分为(68.49±9.67)分,显著高于对照组(60.38±8.72)分(P<0.05);两组治疗前促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)、皮质醇水平差异均无统计学意义(P>0.05);研究组ACTH、皮质醇水平为[(4.26±0.38)pmol/L、(4.38±0.42)μg/dL],均显著低于对照组[(8.03±0.82)pmol/L、(7.38±0.72)μg/dL](P<0.05);研究组不良反应总发生率为14.71%(5/34),显著低于对照组32.35%(11/34)(P<0.05)。结论加味调神解郁汤可有效缓解首发轻中度抑郁症患者的抑郁症状,调节下丘脑-垂体-肾上腺轴(hypothalamic-pituitary-adrenal axis,HPA)功能,提高生存质量,降低不良反应。Objective To study the clinical efficacy of Modified Tiaoshen Jieyu Decoction(加味调神解郁汤)in the treatment of first-episode mild to moderate depression.Methods Sixty-eight patients with first-episode mild to moderate depression in the hospital from June 2018 to June 2021 were selected for this study,they were divided into study group and control group according to the simple lottery method,34 patients in both groups.The control group was treated with paroxetine hydrochloride tablets,and the study group was treated with Modified Tiaoshen Jieyu Decoction combined with paroxetine hydrochloride tablets.The course of treatment was 1 month in both groups.The clinical efficacy,clinical symptom score,Hamilton Depression Scale(HAMD),quality of life scale(QOL)and Pittsburgh sleep quality index(PSQI),and the incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the study group was 91.18%(31/34),which was significantly higher than 64.71%(22/34)of the control group(P<0.05).There was no significant difference in clinical symptom score,HAMD score and PSQI score between the two groups before treatment(P>0.05).After treatment,the clinical symptom score,HAMD score and PSQI score of the study group were[(6.37±1.32)points,(8.17±2.65)points,(4.76±1.29)points],which were significantly lower than those of the control group[(11.63±2.29)points,(12.78±2.97)points,(5.82±1.60)points](P<0.05).The QOL score of the study group was(68.49±9.67)points,which was significantly higher than that of the control group[(60.38±8.72)points](P<0.05).There was no significant difference in the levels of adrenocorticotropic hormone(ACTH)and cortisol between the two groups before treatment(P>0.05).The levels of ACTH and cortisol in the study group were(4.26±0.38)pmol/L and(4.38±0.42)μg/dL,which were significantly lower than those in the control group[(8.03±0.82)pmol/L,(7.38±0.72)μg/dL](P<0.05).The total incidence of adverse reactions in the study group was 14.71%(5/34),wh

关 键 词：轻中度抑郁症 中医治疗 临床症状 生活质量 

分 类 号：R277.7[医药卫生—中医学]