伊伐布雷定联合地高辛治疗对慢性心力衰竭患者心肌损伤标志物及心率震荡的影响  

Impact of Ivabradine Combined with Digoxin on Myocardial Injury Markers and Heart Rate Turbulence in Patients with Chronic Heart Failure

作　　者：韩贝 胡法国 HAN Bei;HU Faguo(Department of Cardiology,Zhengzhou Seventh People's Hospital,Zhengzhou 450016,China)

机构地区：[1]郑州市第七人民医院心内科,河南郑州450016

出　　处：《临床医学工程》2024年第1期25-26,共2页Clinical Medicine & Engineering

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20220832)。

摘　　要：目的探讨伊伐布雷定联合地高辛治疗对慢性心力衰竭(CHF)患者心肌损伤标志物及心率震荡的影响。方法选取2022年1月至2023年2月我院收治的88例CHF患者,随机分为对照组(n=44)和观察组(n=44)。除常规药物治疗外,对照组采用地高辛治疗,观察组采用伊伐布雷定联合地高辛治疗。比较两组的心肌损伤标志物[肌钙蛋白I(cTnI)、N-末端脑钠肽前体(NT-proBNP)及肌酸激酶同工酶(CK-MB)]水平及心率震荡参数[震荡初始(TO)、震荡斜率(TS)]。结果治疗后,两组的cTnI、NT-proBNP、CK-MB水平均低于治疗前,且观察组cTnI、NT-proBNP、CK-MB水平低于对照组(P<0.05)。治疗后,两组的TO低于治疗前,TS高于治疗前,且观察组TO低于对照组,TS高于对照组(P<0.05)。结论伊伐布雷定联合地高辛治疗可明显减轻CHF患者心肌损伤,控制其心率震荡,值得临床推广应用。Objective To explore the impact of ivabradine combined with digoxin on myocardial injury markers and heart rate turbulence in patients with chronic heart failure(CHF).Methods 88 CHF patients admitted to our hospital from January 2022 to February 2023 were selected and randomly divided into control group(n=44)and observation group(n=44).In addition to routine drug treatment,the control group was treated with digoxin,and the observation group was treated with ivabradine combined with digoxin.The levels of myocardial injury markers[troponin I(cTnI),N-terminal pro-brain natriuretic peptide(NT-proBNP)and creatine kinase isoenzyme(CK-MB)]and heart rate turbulence parameters[turbulence onset(TO),turbulence slope(TS)]were compared between the two groups.Results After treatment,the cTnI,NT-proBNP and CK-MB levels of the two groups were lower than those before treatment,and the cTnI,NT-proBNP and CK-MB levels of the observation group were lower than those of the control group(P<0.05).After treatment,the TO of the two groups were lower than those before treatment,and the TS were higher than those before treatment(P<0.05);The TO of the observation group was lower than that of the control group,and the TS was higher than that of the control group(P<0.05).Conclusions Ivabradine combined with digoxin can significantly reduce myocardial injury and control heart rate turbulence in CHF patients,which is worthy of clinical promotion and application.

关 键 词：伊伐布雷定 地高辛 慢性心力衰竭 心肌损伤标志物 心率震荡 

分 类 号：R541.61[医药卫生—心血管疾病]