布托啡诺与曲马多对剖宫产腰硬联合麻醉产妇术中寒战及安全性的meta分析  

Meta-analysis of butorphanol and tramadol on chills and safety in puerperae undergoing cesarean section under combined spinal-epidural anesthesia

作　　者：张辰喜 赵立芳 庞鹏 张勇[1] Zhang Chenxi;Zhao Lifang;Pang Peng;Zhang Yong(Department of Anesthesiology,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院麻醉科,滨州256600

出　　处：《国际医药卫生导报》2024年第2期200-204,共5页International Medicine and Health Guidance News

摘　　要：目的采用meta分析系统评价布托啡诺与曲马多对剖宫产腰硬联合麻醉产妇术中寒战控制有效率和恶心呕吐等不良反应发生率的影响。方法检索中文数据库如维普、万方、中国知网,英文数据库如PubMed、EMbase、Cochrane library,检索自建库至2022年12月的关于布托啡诺及曲马多对剖宫产腰硬联合麻醉产妇术中寒战的随机对照试验(RCT)。采用Cochrane质量评估量表对筛选出的文献进行质量评价,并采用RevMan 5.3对文献内容进行统计分析。结果共有15项RCTs、1293例患者纳入本meta分析。meta分析结果显示,布托啡诺寒战控制有效率高于曲马多[RR=1.07,95%置信区间(CI)(1.04~1.11),P<0.0001],恶心、呕吐等不良反应发生率低于曲马多[RR=0.13,95%CI(0.09~0.21),P<0.00001]。结论布托啡诺可用于剖宫产腰硬联合麻醉术中寒战的控制,不良反应较小,是一种更加有效、更具安全性的麻醉药物。Objective To evaluate the effects of butorphanol tartrate and tramadol on the control of chills and the incidence of adverse reactions such as nausea and vomiting during cesarean section under combined spinal-epidural anesthesia by using a meta-analysis system.Methods The randomized controlled trials(RCTs)of butorphanol tartrate and tramadol on the control of chills during cesarean section under combined spinal-epidural anesthesia were retrieved from the establishment of Chinese databases such as VIP,Wanfang,and CNKI and English databases such as PubMed,EMbase,and Cochrane library to December 2022.Cochrane quality evaluation scale was used to evaluate the quality of the selected literatures,and RevMan 5.3 was used to conduct statistical analysis on the contents of the literatures.Results A total of 15 RCTs including 1293 patients were included in this meta-analysis.The results of meta-analysis showed that the effective control rate of chills with butorphanol tartrate was higher than that of tramadol[RR=1.07,95%confidence interval(CI)(1.04,1.11),P<0.0001],and the incidence of adverse reactions such as nausea and vomiting was lower than that of tramadol[RR=0.13,95%CI(0.09,0.21),P<0.00001].Conclusion Butorphanol tartrate can be used to control chills during cesarean section under combined spinal-epidural anesthesia,with less adverse reactions,which is a more effective and safer anesthetic drug.

关 键 词：布托啡诺 曲马多 剖宫产 腰硬联合麻醉 寒战 恶心呕吐 META分析 

分 类 号：R614[医药卫生—麻醉学]