平肝祛湿同治法对中青年高血压患者中医证候、不良事件及预后相关指标的影响  

Effects of Pingan qushi prescription on traditional Chinese medicine syndrome,adverse events,and compliance in young and middle-aged patients with hypertension

作　　者：柴松波 杜亚康 张淑娟[2] 兀江波 王晓飞 CHAI Songbo;DU Yakang;ZHANG Shujuan;WU Jiangbo;WANG Xiaofei(Department of Cardiology,Sanmenxia Traditional Chinese Medicine Hospital,Sanmenxia 472000,China;Department of Cardiology,Second Clinical School of Henan University of Traditional Chinese Medicine,Zhengzhou 450002,China;Pharmacy Department of Sanmenxia Traditional Chinese Medicine Hospital,Sanmenxia 472000,China)

机构地区：[1]三门峡市中医院心病科,河南三门峡472000 [2]河南中医药大学第二临床医学院心病科,郑州450002 [3]三门峡市中医院药剂科,河南三门峡472000

出　　处：《中国医科大学学报》2024年第1期8-14,共7页Journal of China Medical University

基　　金：国家自然科学基金(82204981);河南省中医药拔尖人才培养项目专项课题(2022ZYBJ29)。

摘　　要：目的探讨平肝祛湿同治法对中青年社区高血压患者中医证候、不良事件及预后相关指标的影响。方法选取中青年高血压患者132例,随机分为2组,剔除病例后,最终每组各64例纳入研究。对照组采用厄贝沙坦片治疗,观察组在对照组基础上加用平肝祛湿同治法治疗,均连续治疗2个月。比较2组血压、疗效、中医证候积分、安全性、不良事件、预后相关指标。结果观察组中医和西医总有效率(96.88%、92.19%)均高于对照组(82.52%、78.13%),差异均有统计学意义(P=0.005,P=0.025);治疗1、2个月后观察组血压、证候积分、醛固酮、血浆肾素活性、血浆血管紧张素Ⅱ、内皮素-1均低于对照组,一氧化氮高于对照组,差异均有统计学意义(均P<0.05);2组不良反应发生率比较,差异无统计学意义(P>0.05);观察组治疗期间不良事件发生率(1.56%)与对照组(10.94%)比较,差异无统计学意义(P>0.05)。结论平肝祛湿同治法治疗中青年高血压患者能进一步改善患者症状,提高血压控制效果,促进预后改善。Objective To investigate the effects of the Pingan qushi prescription on traditional Chinese medicine syndrome,adverse events,and compliance in young and middle-aged hypertensive patients.Methods One hundred thirty-two young and middle-aged patients with hypertension were selected and randomly divided into two groups.After elimination,64 cases were included in each group.For 2 months,the control group was treated with irbesartan tablets,and the observation group underwent the Pingan qushi prescription based on the control group.The blood pressure,curative effect,traditional Chinese medicine syndrome score,safety,adverse events,and prognosis-related indicators were compared between the two groups.Results The total effective rate of the observation group(96.88%,92.19%)was higher than that of the control group(82.52%,78.13%),and the difference was statistically significant(P=0.005,P=0.025).After 1 and 2 months of treatment,the blood pressure,syndrome scores,ALD,PRA,AngⅡ,and ET-1 in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).There was no statistically significant difference(P>0.05)in the incidence of adverse events during treatment between the observation group(1.56%)and control group(10.94%).Conclusion The treatment of young and middle-aged community patients with hypertension undergoing the Pingan qushi prescription can further improve patients’symptoms,increase blood pressure control,promote prognosis improvement.

关 键 词：平肝祛湿同治法 中青年 高血压 

分 类 号：R259.441[医药卫生—中西医结合]