奇楠沉香中2个新的倍半萜类化合物  

Two new sesquiterpenes in Qi-nan Aquilariae Lignum Resinatum

作　　者：陈德力[1] 马国需[1,2] 刘会梅 王灿红 刘洋洋[1] 杨云[1] 魏建和[1,2] CHEN De-li;MA Guo-xu;LIU Hui-mei;WANG Can-hong;LIU Yang-yang;YANG Yun;WEI Jian-he(Hainan Branch Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Haikou 570311,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China)

机构地区：[1]中国医学科学院,北京协和医学院,药用植物研究所海南分所,海南海口570311 [2]中国医学科学院 ,北京协和医学院,药用植物研究所,北京100193

出　　处：《中国中药杂志》2023年第23期6403-6407,共5页China Journal of Chinese Materia Medica

基　　金：海南省重点研发计划项目(ZDYF2020111,ZDYF2022SHFZ030);中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-032);国家自然科学基金青年基金项目(82204657)。

摘　　要：采用硅胶柱色谱、薄层色谱以及半制备高效液相色谱对奇楠沉香超临界提取物进行化学成分研究。从中分离得到1个榄香烷型和1个桉烷型倍半萜类化合物,通过MS、UV、IR、NMR和ECD等波谱技术鉴定其结构,分别鉴定为奇楠醇C(1)、奇楠醇D(2),经检索均为新化合物。采用体外法测定化合物对皮质酮(CORT)诱导PC12细胞损伤的保护作用,结果表明化合物1和2对CORT诱导PC12细胞损伤具有一定的保护作用。This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan Aquilariae Lignum Resinatum by silica gel column chromatography,thin-layer chromatography,and semi-preparative high-performance liquid chromatography.One new elemane-type and one new eudesmane-type sesquiterpene compounds were isolated from the extract,and their structures were identified by MS,UV,IR,NMR,and ECD spectroscopic techniques,and named aquqinanol C(1)and aquqinanol D(2).Both compounds are novel compounds.The neuroprotective effect of the compounds on CORT-induced PC12 cell damage was determined in vitro.The results showed that compounds 1 and 2 exhibited a certain protective effect against CORT-induced damage in PC12 cells.

关 键 词：奇楠沉香 榄香烷型倍半萜 桉烷型倍半萜 神经保护 

分 类 号：R284.1[医药卫生—中药学]