乳核散结片抗炎镇痛的药理实验研究  

Pharmacological Study of Ruhe Sanjie Tablet for Anti-inflammation and Analgesia

作　　者：黄秋凌 郑明翠 宁娜 HUANG Qiuling;ZHENG Mingcui;NING Na(Guangzhou Baiyunshan Zhongyi Pharmaceutical Co.,Ltd.,Guangzhou 510530,China;Guangzhou Baiyunshan Qixing Pharmaceutical Co.,Ltd.,Guangzhou 510530,China)

机构地区：[1]广州白云山中一药业有限公司,广州510530 [2]广州白云山奇星药业有限公司,广州510530

出　　处：《世界中医药》2023年第22期3202-3206,共5页World Chinese Medicine

基　　金：广东省重点领域研发计划项目(2020B1111110004)。

摘　　要：目的:探讨乳核散结片的抗炎及镇痛作用。方法:用SD大鼠棉球肉芽肿实验和二甲苯致小鼠毛细血管通透性增加实验,观察乳核散结片的抗炎作用;同时建立冰醋酸致小鼠扭体实验,观察乳核散结片的止痛作用。结果:乳核散结片低、中、高剂量组均能显著抑制大鼠肉芽增生,与空白对照组比较,差异均有统计学意义(均P<0.05),其抑制率分别为30.0%、47.4%、53.6%,且呈量效关系。乳核散结片低、中、高剂量组均能有效降低小鼠毛细血管通透性,蓝斑光密度(OD)值与同期空白对照组比较,差异均有统计学意义(均P<0.001),其对毛细血管通透性抑制率分别为47.6%、55.0%、65.2%,并呈量效关系。乳核散结片低、中、高剂量组均能有效减少冰醋酸致小鼠扭体次数(P<0.001),其镇痛抑制率分别为34.2%、42.0%、51.5%,呈量效关系。结论:乳核散结片药理实验研究表明其具有抗炎及镇痛作用。Objective:To investigate the anti-inflammatory and analgesic effects of Ruhe Sanjie Tablet.Methods:Cotton pellet-induced granuloma formation of Sprague Dawley(SD) rats and the increase in capillary permeability of mice induced by xylene were used to observe the anti-inflammatory effect of Ruhe Sanjie Tablet.The acetic acid writhing experiment in mice was established to observe the analgesic effect of the prescription.Results:The low-,medium-and high-dose Ruhe Sanjie Tablet inhibited the proliferation of rat granulation tissue,and there were differences compared with the blank control group(all P<0.05).The inhibition rates of the three doses were 30.0%,47.4% and 53.6%,respectively,showing a dose-effect relationship.Ruhe Sanjie Tablet at low,medium and high doses reduced the capillary permeability of mice,and the optical density(OD) was lower than that in the blank control group(all P<0.001).The inhibition rates of capillary permeability were 47.6%,55.0% and 65.2%,respectively,with a dose-effect relationship.Ruhe Sanjie Tablet at each dose lowered the number of writhing induced by acetic acid in mice(P<0.001),and the analgesic inhibition rates at low,medium and high dose were 34.2%,42.0% and 51.5%,respectively,presenting a dose-effect relationship.Conclusion:Pharmacological studies of Ruhe Sanjie Tablet indicates that it has anti-inflammatory and analgesic effects.

关 键 词：乳核散结片 抗炎 镇痛 疗效 药理实验 毛细血管通透性 结缔组织增生 乳癖消 

分 类 号：R285.5[医药卫生—中药学]