小金胶囊联合中药面膜治疗痰瘀结聚型中重度痤疮的临床观察  

Clinical Efficacy of Xiaojin Capsule Combined with Chinese Herbal Mask in the Treatment of Moderate and Severe Acne with Phlegm and Blood Stasis

作　　者：李雪[1] 李元文[2] 蔡玲玲[2] 任雪雯 邓宇童 肖飞 LI Xue;LI Yuanwen;CAI Lingling;REN Xuewen;DENG Yutong;XIAO Fei(Beijing University of Chinese Medicine,Beijing 100029,China;Department of Dermatology,Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China;Jianmin Group Children′s Pharmaceutical Research Institute,Wuhan 430052,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东方医院皮肤科,北京100078 [3]健民集团儿童药物研究院,武汉430052

出　　处：《世界中医药》2023年第22期3239-3244,3249,共7页World Chinese Medicine

基　　金：第七批全国老中医药专家学术经验继承工作项目(国中医药人教函[2022]76号);北京中医药大学研究生自主课题(2019-JYB-XS-216)——小金胶囊治疗结节囊肿型痤疮(痰瘀结聚证)的临床研究。

摘　　要：目的:观察小金胶囊联合中药面膜治疗痰瘀结聚型中重度痤疮的临床疗效,并评价疗效与痤疮分级(Ⅱ、Ⅲ、Ⅳ级)的相关性。方法:选取2019年2月至2019年12月北京中医药大学东方医院收治的痰瘀结聚型80例中重度痤疮患者作为研究对象,采用随机数字表法分为观察组和对照组,每组40例。观察组予以小金胶囊口服,对照组予以丹参酮胶囊口服,同时2组均给予中药面膜外敷,疗程均为4周。比较2组患者治疗前后的皮损、中医证候、生命质量评分,并将3项评分的改善情况与痤疮分级进行相关性分析,记录不良反应。结果:共收集有效病例73例,其中观察组38例,对照组35例。观察组的皮损评分总有效率为92.11%,高于对照组的68.57%(P<0.01);对于中医证候的总有效率,观察组中医证候总有效率为94.74%,高于对照组的68.57%(P<0.01)。观察组中不同痤疮分级患者的中医证候评分变化率差异有统计学意义(P<0.05),其中Ⅱ级、Ⅲ级的变化率均高于Ⅳ级(P<0.05)。研究期间观察组未出现不良反应,对照组出现2例不良反应,停药后缓解。结论:小金胶囊联合中药面膜对痰瘀结聚型中重度痤疮疗效确切,且对患者中医证候的改善效果与痤疮分级有关,其中Ⅱ级、Ⅲ级患者中医证候的改善效果比Ⅳ级患者更明显,药物安全性较好。Objective:To observe the clinical efficacy of Xiaojin Capsule combined with Chinese herbal mask in the treatment of moderate and severe acne with phlegm and blood stasis,and to evaluate the correlation between the efficacy and the grades(Ⅱ,Ⅲ and Ⅳ) of acne.Methods:A total of 80 moderate and severe acne patients with phlegm and blood stasis admitted to Dongfang Hospital of Beijing University of Chinese Medicine from February 2019 to December 2019 were selected as the study objects.They were divided into observation group and control group using random number table method,with 40 in each group.The observation group was given Xiaojin Capsule orally,while the control group was given Tanshinone Capsule orally.Additionally,the two groups were given external application of Chinese herbal mask.The treatment lasted for 4 weeks.The scores of skin lesions,traditional Chinese medicine(TCM) syndromes and quality of life in the two groups were compared,and the correlation between the improvement in the three scores and acne grades was analyzed.Moreover,the adverse reactions were recorded.Results:A total of 73 effective cases were collected,including 38 in observation group and 35 in control group.The total effective rate of skin lesions in observation group was 92.11%,higher than 68.57% in control group(P<0.01).The total effective rate of TCM syndromes in observation group was 94.74%,higher than 68.57% in control group(P<0.01).There was difference in the change of TCM syndrome score in observation group in different acne grades(P<0.05).Specifically,the change rate of grade Ⅱ and grade Ⅲ patients was higher than that of grade Ⅳ patient(P<0.05).During treatment,no adverse reaction was found in observation group,while there were 2 cases of adverse reactions in control group,which were relieved after discontinuation.Conclusion:Xiaojin Capsule combined with Chinese herbal mask shows definite curative efficacy and high safety in treating moderate and severe acne with phlegm and blood stasis.There is a relationship betwee

关 键 词：丹参酮胶囊 临床疗效 痰瘀结聚证 小金胶囊 中药面膜 中重度痤疮 不良反应 中医证候 

分 类 号：R275[医药卫生—中医皮科]