具有神经保护活性的中药治疗缺血性脑卒中的研究进展  

Traditional Chinese Medicine with Neuroprotective Activity in Treatment of Ischemic Stroke:A Review

作　　者：李晓星 刘艺 许博成 李霁 于锋 LI Xiaoxing;LIU Yi;XU Bocheng;LI Ji;YU Feng(School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学基础医学与临床药学学院,南京211198

出　　处：《世界中医药》2023年第22期3294-3298,共5页World Chinese Medicine

基　　金：国家自然科学基金项目(81503133);中央高校基本科研专项业务费资金项目(3010010004)。

摘　　要：缺血性脑卒中(IS)是一种常见的以中老年人为主要发病人群的脑血管疾病,已成为危害人类生命的一项重大挑战,给社会经济带来沉重负担。具有神经保护的中药活性成分及其复方基于其多靶点模式发挥多重有益作用,包括保护血脑屏障、抑制神经炎症、抗氧化应激等,对IS有巨大的治疗潜力和良好的应用前景。Ischemic stroke(IS) is a common type of cerebrovascular diseases that mainly occurred in the middle-aged and elderly.It has become a major challenge that endangers human life,causing a heavy socio-economic burden.Based on the multi-target mode,the active ingredients of traditional Chinese medicine(TCM) and TCM compound with neuroprotective activity exert beneficial effects,including protection of blood-brain barrier,inhibition of neuroinflammation and anti-oxidative stress.Therefore,they have a great therapeutic potential and application prospect for IS.

关 键 词：缺血性脑卒中 活性成分 中药复方 神经保护作用 氧化应激 兴奋毒性 神经炎症 血脑屏障 

分 类 号：R282[医药卫生—中药学] R743[医药卫生—中医学]