补肾温阳汤治疗卵巢储备功能低下临床研究  

Clinical Study on the Treatment of Low Ovarian Reserve Function with Kidney-Tonifying and Yang-Warming Decoction

作　　者：赵艳晓[1] 毛常峰 ZHAO Yanxiao;MAO Changfeng(Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China,450008)

机构地区：[1]河南中医药大学第三附属医院,河南郑州450008

出　　处：《河南中医》2024年第1期87-91,共5页Henan Traditional Chinese Medicine

基　　金：庞玉琴全国名老中医药专家传承工作室{国中医药人教函[2022]75号};河南省中医药传承与创新人才工程(仲景工程)中医药拔尖人才培养项目{豫卫中医函[2021]15号}。

摘　　要：目的:观察补肾温阳汤治疗卵巢储备功能低下的临床疗效。方法:将60例卵巢储备功能低下患者按照随机数字表法分为对照组和观察组,每组各30例。对照组给予戊酸雌二醇/雌二醇环丙孕酮片治疗,观察组在对照组治疗的基础上加用补肾温阳汤。比较两组患者的临床疗效以及治疗前后中医证候积分、激素水平[卵泡刺激素(follicle-stimulating hormone,FSH)、雌二醇(estradiol,E_(2))、黄体生成素(luteinizing hormone,LH)、抗米勒管激素(anti mullerian hormone,AMH)]、卵巢功能指标[卵巢体积、卵巢窦卵泡数、卵巢间质动脉收缩期峰值流速(peak systolic velocity,PSV)]变化情况。结果:观察组有效率为93.33%,对照组有效率为73.33%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后各项中医证候积分低于本组治疗前,且治疗后观察组低于对照组(P<0.05)。两组患者治疗后血清FSH、LH低于本组治疗前,E_(2)高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后卵巢窦卵泡数、PSV高于本组治疗前,且治疗后观察组高于对照组(P<0.05)。结论:补肾温阳汤治疗卵巢储备功能低下,可改善患者的临床症状,调节激素水平,促进卵巢功能恢复。Objective:To observe the clinical efficacy of Kidney-Tonifying and Yang-Warming Decoction on low ovarian reserve function.Methods:A total of 60 patients with low ovarian reserve function were randomly divided into the control group and the observation group,with 30 cases in each group.The control group was treated with Estradiol Valerate Tablets/Estradiol Cyproterone Tablets,while the observation group was treated with Kidney-Tonifying and Yang-Warming Decoction on the basis of the control group.The clinical efficacy,and the changes in TCM syndrome scores,hormone levels [including follicle-stimulating hormone(FSH),estradiol(E_(2)),luteinizing hormone(LH),anti-mullerian hormone(AMH)],ovarian function indexes [including ovarian volume,number of ovarian antral follicles,peak systolic velocity(PSV) of ovarian interstitial arteries] before and after treatment between two groups were compared.Results:The effective rate of the observation group was 93.33%,while that of the control group was 73.33%.The difference was statistically significant(P<0.05).After treatment,the scores of various TCM syndromes in both groups were lower than those before treatment,and the observation group′s TCM syndrome scores were lower than those of the control group(P<0.05);The serum FSH and LH levels of the two groups were lower than those before treatment,while the E_((2)) level was higher than that before treatment,and all the differences between the two groups were statistically significant(P<0.05);The number of ovarian antral follicles and PSV in both groups were higher than those before treatment,and the observation group′s above indexes were higher than those of the control group after treatment(P<0.05).Conclusion:Kidney-Tonifying and Yang-Warming Decoction can improve the clinical symptoms of patients with low ovarian reserve function,regulate hormone levels,and promote the recovery of ovarian function.

关 键 词：卵巢储备功能低下 补肾温阳汤 戊酸雌二醇片/雌二醇环丙孕酮片 中西医结合疗法 

分 类 号：R271.911.75[医药卫生—中西医结合]