Effectiveness of Shenshu Guanxin recipe granules(参术冠心方颗粒)for improving exercise tolerance in patients with stable angina pectoris:a randomized,double-blind,placebo-controlled trial  

作　　者：JIN Xiao WU Bingxin WU Huanlin XU Danping 

机构地区：[1]Department of Traditional Chinese Medicine,the First Affiliated Hospital of Jinan University,Guangzhou 510630,China [2]Department of Cardiology,Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510000,China [3]Department of Cardiology,Dongzhimen Hosipital,Beijing 100029,China [4]Department of Traditional Chinese Medicine,the Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen 518033,China

出　　处：《Journal of Traditional Chinese Medicine》2023年第6期1227-1233,共7页中医杂志（英文版）

基　　金：Guangdong Medical Foundation:Exploring the Mechanism of Shenshu Guanxin Formula in Intervention of Myocardial Ischemia Based on MiR-24 Mediated Bim/Caspase Apoptosis Signal Pathway (No.A2021349);the Fundamental Research Funds for the Central Universities:Exploring the Intervention of Shenshu Guanxin Formula on Myocardial Ischemia Based on MiR-24 Mediated Bim/Caspase Apoptosis Signal Pathway Mechanism Research (No.21621062);the Science and Technology Innovation Projects of Shenzhen:to Study the Mechanism of Hesperidin in Improving Heart Failure Based on Myocardial Inflammation Mediated by Mt DNA-s GAS-STING Signaling Pathway (No.JCYJ20220530144212026)

摘　　要：OBJECTIVE:To assess the effectivess of Shenshu Guanxin recipe granules(参术冠心方颗粒,SGR)in improving exercise tolerance and the quality of life in patients with Stable Angina Pectoris(SAP).METHODS:A total of 189 patients were consecutively enrolled between December 2012 and December 2014.The included patients were randomly assigned to SGR and placebo groups.The primary endpoints included mainly the results of treadmill exercise test and Seattle Angina Questionnaire(SAQ)during 12 weeks of treatment.RESULTS:After 12 weeks of treatment,SGR extended the time of exercise-induced ST-segment depression of 0.1 MV,lowered the maximum ST-segment depression,and shortened the duration of ST-segment depression in patients with SAP in southern China.Besides,the study also proved that SGR could improve the quality of life and functional status of patients with SAP.CONCLUSIONS:SGR showed a positive effect on exercise tolerance compared with the placebo besides optimal medical therapy.Also,the study proved that SGR could improve the SAQ score of the patients.

关 键 词：exercise tolerance ANGINA stable Seattle Angina Questionnaire Shenshu Guanxin recipe granules 

分 类 号：R259[医药卫生—中西医结合]