2018-2022年山东省聊城市手足口病流行病学特征及病原学分析  

Analysis on epidemiological and etiological characteristics of hand-foot-mouth disease in Liaocheng city,Shandong province from 2018 to 2022

作　　者：董月晗 周璞[2] 徐可心[2] 尹慧慧 刘九银 王好迪 DONG Yue-han;ZHOU Pu;XU Ke-xin;YIN Hui-hui;LIU Jiu-yin;WANG Hao-di(School of Public Health,Zhengzhou University,Henan 450000,China;Institute of Virology,Liaocheng City Center for Disease Control and Prevention)

机构地区：[1]郑州大学公共卫生学院,河南450000 [2]聊城市疾病预防控制中心病毒所

出　　处：《预防医学论坛》2023年第11期836-838,845,共4页Preventive Medicine Tribune

基　　金：山东省医药卫生科技发展计划项目(2019WS108)。

摘　　要：目的分析2018-2022年山东省聊城市手足口病(HFMD)流行病学特点及病原学情况。方法2018-2022年聊城市HFMD病例资料来源于中国疾病预防控制信息系统,人口资料来源于聊城市统计年鉴。率的比较采用χ^(2)检验,病原学样本采用实时荧光定量PCR法进行核酸检测。结果2018-2022年聊城市累计报告HFMD病例5241例,其中重症2例,无死亡病例。年发病率为3.3/10万~41.4/10万,2018年最高,2022年最低,2018-2022年年均发病率为17.3/10万。2018-2019年发病基本集中在5-8月,2020-2022年发病无明显高峰。2018-2022年聊城市HFMD病例主要为5岁以下儿童,占95%;男、女性年平均发病率分别为21/10万、13.3/10万,比较差异有统计学意义(χ^(2)=261,P<0.05)。散居儿童占79.71%(4178/5241),幼托儿童占16.54%(867/5241),学生、工人、农民、教师、商业服务人员、医务人员、干部职员、退休人员和家务待业人员占3.75%(196/5241)。各区县均有发病,年发病率排前3的分别为东昌府区、高唐县和茌平区,冠县最低,东昌府区、高唐县和茌平区年平均发病率高于全市年平均发病率。分离出的病毒株中,EV71占3.8%,CoxA16占12.0%,其他肠道病毒占51.3%。结论2018-2022年聊城市HFMD呈现下降趋势,散居儿童为高危人群,其他肠道病毒成为流行株。Objective To analyze the epidemiology and etiological characteristics of hand?foot?mouth disease(HFMD)in Liaocheng city from 2018 to 2022.Methods Data on HFMD cases in Liaocheng city from 2018 to 2022 were obtained from the China Information System for Disease Control and Prevention,and population data were obtained from the Liaocheng City Statistical Yearbook.The rates were compared byχ^(2)test.Fluorescence quantitative RT-PCR method was used to conduct nucleic acid detection.Results A total of 5241 cases of HFMD were reported in Liaocheng city from 2018 to 2022,of which 2 were severe cases and there were no fatal cases.The annual incidence was 3.3/10~5 to 41.4/10~5,with the highest in 2018 and the lowest in 2022,and the average annual incidence was 17.3/10~5 from 2018 to 2022.In 2018-2019,the cases were concentrated in May-August,and there was no obvious peak in 2020 to 2022.In 2018 to 2022,HFMD cases in Liaocheng city were mainly children under 5 years of age,accounting for 95%;the average annual incidence rates of males and females were 21/10~5 and 13.3/10~5,respectively,with a statistically significant difference in comparison(χ^(2)=261,P<0.05).Scattered children accounted for 79.71%(4178/5241),nursery children accounted for 16.54%(867/5241),and students,workers,peasants,teachers,commercial service workers,medical workers,cadres and employees,retired persons and home helpers accounted for 3.75%(196/5241).All districts and counties had cases,with the top 3 annual incidences being Dongchangfu district,Gaotang county and Chiping district,and Guan county being the lowest,while the average annual incidences in Dongchangfu district,Gaotang county and Chiping district were higher than the city's average annual incidence.Of the virus strains isolated,EV71 accounted for 3.8%,CoxA16 accounted for 12.0%,and other enteroviruses accounted for 51.3%.Conclusion From 2018 to 2022,hand-foot-mouth disease showed a downward trend in Liaocheng City.Other pathogens was thedominant.And scattered children were high-risk groups.W

关 键 词：手足口病 流行病学 病原学 肠道病毒 儿童 

分 类 号：R512.5[医药卫生—内科学] R181.12[医药卫生—临床医学]